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A kind of method for extracting Scutellarin from Scutellaria barbata

A technology of scutellarin and extraction method, which is applied in the field of purification of ingredients in Scutellaria barbata, which can solve the problems of high ointment yield, insufficient depth, and lack of parameters such as diameter-to-height ratio in the purified part

Active Publication Date: 2018-08-28
HEBEI YILING MEDICINE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, it has been reported in the literature that the macroporous adsorption resin method is used to purify and enrich the extract of Scutellaria barbata, but it is not deep enough, lacking parameters such as the diameter-to-height ratio required for actual production, and has not solved the ointment rate of the purified part. Problems with Taller and Darker Colors

Method used

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  • A kind of method for extracting Scutellarin from Scutellaria barbata
  • A kind of method for extracting Scutellarin from Scutellaria barbata
  • A kind of method for extracting Scutellarin from Scutellaria barbata

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Embodiment 1

[0093] A method for purifying Scutellaria barbatae, comprising the following steps:

[0094] A. Extraction: Get Scutellaria barbata medicinal material, add 14 times the amount of 70% ethanol, then heat and reflux to extract 3 times, each time for 1 hour, reclaim ethanol, slowly add 1% hydrochloric acid solution to the extract, adjust the pH to 3.0, Then centrifuge to obtain the supernatant I and the precipitate, then wash the precipitate with 1 times the amount of medicinal material in water, and then centrifuge to obtain the supernatant II. Combine the two supernatants, and then concentrate to obtain a crude drug concentration of 0.15g.mL -1 the concentrate;

[0095] B. Purification: The loading volume is 150ml, and the AB-8 macroporous adsorption resin is weighed according to the mass ratio of the crude drug to the resin volume of 1:2. The diameter-height ratio of the AB-8 macroporous adsorption resin is 1:5, and the concentrate sample, the sample loading flow rate is 2 BV / ...

Embodiment 2

[0097] A method for purifying Scutellaria barbatae, comprising the following steps:

[0098]A, extraction: get Scutellaria barbata medicinal material, 14 times the amount of 80% ethanol, then heat and reflux extraction 3 times, each time for 1 hour, reclaim ethanol, slowly add 1% hydrochloric acid solution to the extract, adjust the pH to 3.3, then Centrifuge to obtain supernatant I and precipitate, then wash the precipitate with 1 times the amount of medicinal material in water, and then centrifuge to obtain supernatant II, combine the two supernatants, and then concentrate to obtain a crude drug concentration of 0.2g.mL -1 the concentrate;

[0099] B. Purification: The loading volume is 90ml, and the AB-8 macroporous adsorption resin is weighed according to the mass ratio of the crude drug to the resin volume of 1:2. The diameter-to-height ratio of the AB-8 macroporous adsorption resin is 1:5. sample, the sample loading flow rate is 2 BV / h, the washing volume is 4 BV, the e...

Embodiment 3

[0101] A method for purifying Scutellaria barbatae, comprising the following steps:

[0102] A, extraction: get Scutellaria barbata medicinal material, 14 times the amount of 90% ethanol, then heat and reflux extraction 3 times, each time for 1 hour, reclaim ethanol, slowly add 1% hydrochloric acid solution to the extract, adjust the pH to 3.2, then Centrifuge to obtain supernatant I and precipitate, then wash the precipitate with 1 times the amount of medicinal material in water, then centrifuge to obtain supernatant II, combine the two supernatants, and then concentrate to obtain a crude drug concentration of 0.17g.mL -1 the concentrate;

[0103] B. Purification: The loading volume is 75ml, and the AB-8 macroporous adsorption resin is weighed according to the mass ratio of the crude drug to the resin volume of 1:2. The diameter-height ratio of the AB-8 macroporous adsorption resin is 1:5, and the concentrated solution sample, the sample loading flow rate is 2 BV / h, the wash...

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Abstract

The invention discloses a method for extracting scutellarin from Scutellaria barbata, which belongs to the field of traditional Chinese medicine and consists of extraction and purification steps. The method of the invention has low leakage rate and high elution rate.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a method for purifying ingredients in Scutellaria barbata. Background technique [0002] Scutellaria barbata, also known as Bingtoucao, toothbrush grass, etc., is mainly produced in North China, Central South, East China, South China, Southwest China and other places. It is a plant of the genus Scutellaria barbatae ( Scutellaria barata D. Don) dry whole herb. The medicine tastes pungent, bitter, and cold in nature, and has the effects of clearing away heat and detoxification, dispelling blood stasis, hemostasis, and relieving pain. It is used to treat diseases such as cancer, hepatitis, sore throat, lung abscess, urethritis, dysentery and snake bites. [0003] The flavonoids in Scutellaria barbata are the main active parts, which have a variety of physiological activities, such as inhibiting the proliferation of uterine fibroid cells, inhibiting Staphy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/07C07H1/08
CPCC07H1/08C07H17/07
Inventor 刘丹郭珊珊王曙宾
Owner HEBEI YILING MEDICINE INST
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