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Topical drug combination for promotion of fracture healing and application

A kind of external medicine and fracture healing technology, applied in the field of traditional Chinese medicine, can solve the problems of ignoring the pathological characteristics of osteoporosis, lack of fracture healing, poor fracture healing, etc., achieve significant social and economic significance, promote healing, and improve biomechanical properties Effect

Inactive Publication Date: 2014-12-31
青岛申达高新技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, due to the lack of sufficient understanding of the characteristics of fracture healing and the lack of specific drugs to promote fracture healing, people often ignore the pathological characteristics of osteoporosis in the treatment of fractures in the elderly, which eventually leads to poor fracture healing or refractures

Method used

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  • Topical drug combination for promotion of fracture healing and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] The preparation of embodiment 1 Chinese medicine gel

[0013] (1) Preparation of materials: take by weighing 200 kg of cleaned cut ginseng and 30 kg of star anise maple according to the prescription, and set aside;

[0014] (2) Decoction: add water to decoct, add water to each pot of the first decoction to be 8 times the total amount of medicinal materials, heat and boil for 3 hours, and the obtained extract is filtered through a 200-mesh filter and enters the precipitation tank; the second decoction adds the amount of medicinal materials 6 times of water is heated and extracted, and kept boiling for 3 hours, and the obtained extract is filtered through a 200-mesh filter and entered into a sedimentation tank;

[0015] (3) Precipitation: the extract in the precipitation tank was precipitated for 36 hours, and the supernatant was extracted and filtered through a 200-mesh filter into a three-effect evaporator, and the sediment was treated as waste;

[0016] (4) Concentrat...

Embodiment 2

[0020] The preparation of embodiment 2 Chinese medicine gel

[0021] (1) Preparation of materials: take by weighing 210kg of cleaned cut ginseng and 26kg of star anise maple according to the prescription, and set aside;

[0022] (2) Decoction: add water to decoct, add water to each pot of the first decoction to be 8 times the total amount of medicinal materials, heat and boil for 3 hours, and the obtained extract is filtered through a 200-mesh filter and enters the precipitation tank; the second decoction adds the amount of medicinal materials 4 times of water is heated and extracted, and kept boiling for 3 hours, and the obtained extract is filtered through a 200-mesh filter and entered into a sedimentation tank;

[0023] (3) Precipitation: The extract in the precipitation tank was precipitated for 24 hours, and the supernatant was extracted and filtered through a 200-mesh filter into a three-effect evaporator, and the sediment was treated as waste;

[0024] (4) Concentratio...

Embodiment 3

[0032] Example 3 Experimental Research of Chinese Medicine Gel Promoting Fracture Healing in Rats

[0033] Fifty-five adult female SD rats were selected, weighing 180-220 g, 10 for the preliminary experiment and 45 for the experiment. Except for 5 rats that were fed with normal saline 8ml / kg / d as the control group, after the other 50 rats were continuously fed with retinoic acid 80mg / kg / d for 15 days, 5 rats in the control group and 5 rats in the experimental group were randomly selected for investigation. The T value of the bone density was used to observe the preparation of the model. After confirming that the model was successfully replicated, the remaining 45 model rats were anesthetized with 10% chloral hydrate by intraperitoneal injection of 2ml / kg body weight, and the right thigh of the rat was shaved before giving After local anesthesia with 1% lidocaine, a 2cm incision was made on the right thigh to separate the femur from the intermuscular space to expose the femur, ...

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Abstract

The present invention discloses a topical drug combination for promotion of fracture healing and application, the topical drug combination comprises an active component and a medicinal supplementary material, and the active component is prepared from root of wallich swallowwort and alangium platanifolium as Chinese herbal medicine raw materials. The topical drug combination can promote the fracture healing, and improve the biomechanical characteristics of compression resistance and fracture resistance of bones of elderly osteoporotic patients through increase of femoral maximum load and elastic ratio of osteoportic fracture patients.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to an external pharmaceutical composition for promoting fracture healing and its application. Background technique [0002] Fracture refers to a disease in which bone is partially or completely broken due to trauma or pathology. The main clinical manifestations are: localized pain and tenderness at the fracture site, local swelling and ecchymosis, or complete loss of limb function, and limb deformity and abnormal activities in complete bone. With the acceleration of the aging process of the population and the change of people's lifestyle, osteoporosis and the resulting fractures have become common and frequently-occurring diseases. At present, due to the lack of sufficient understanding of the characteristics of fracture healing and the lack of specific drugs to promote fracture healing, people often ignore the pathological characteristics of osteop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/27A61P19/08A61P19/10
Inventor 江志鑫
Owner 青岛申达高新技术开发有限公司
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