Nanostructures for treating cancers and other conditions
A nanostructure, cancer technology, applied in metabolic diseases, allergic diseases, medical preparations containing active ingredients, etc., can solve the problems of large structure size, wide size distribution, short stability, etc.
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[0197] This example demonstrates the use of synthetic nanostructures such as HDL-NPs to treat cancers such as SR-B1 expressing cancers.
[0198] Functional biomimetic high-density lipoprotein nanoparticles (HDL-NPs) are described as a potential therapy for B-cell lymphoma. The HDL-NPs appear to act through their ability to target type B-1 scavenger receptors (SR-B1) and their functional ability to mask cholesterol. Thus, the HDL-NPs are surface chemical mimics of spherical HDL; however, the gold nanoparticle template used to control the size and shape of the HDL-NPs occupies some space in the particle normally reserved for esterified cholesterol. Thus, like native HDL, HDL-NP takes up SR-B1 but provides very little cholesterol to the cell. At the same time, HDL-NP masks free cellular cholesterol on its surface. The data here demonstrate that HDL-NP targets SR-B1 expressed by B-cell lymphoma cell lines, maximizes cholesterol efflux when compared to native HDL, and induces apo...
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