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Detection method for neosigmine methylsuifate injection

A kind of technology of neostigmine methylsulfate and detection method, applied in detection field

Inactive Publication Date: 2014-12-24
SHANGHAI XINYI JINZHU PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Existing testing methods for Neostigmine Methosulfate Injection cannot detect the content of related substances

Method used

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Embodiment Construction

[0009] The detection method of neostigmine methylsulfate injection of the present invention comprises the following steps:

[0010] Step 1: Dissolve iodine and potassium iodide in water, add hydrochloric acid and shake well, filter with a vertically fused glass filter, accurately measure 2ml of the above solution, put it into a 100ml measuring bottle, add 1mg of neostigmine methylsulfate, and dilute with water to the mark and shake well to form a reference substance solution;

[0011] Step 2: Accurately measure 2ml of Neostigmine Methosulfate Injection, put it into a 100ml measuring bottle, add water to dilute to the mark and shake well to form a solution of the test product;

[0012] Step 3, draw the reference substance solution and the test solution, and inject them into the liquid chromatograph for determination.

[0013] The invention can detect the content level of related substances.

[0014] Although the specific implementations of the present invention have been desc...

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Abstract

The invention discloses a detection method for a neosigmine methylsuifate injection. The detection method comprises the following steps of 1, dissolving iodine and potassium iodide in water, adding hydrochloric acid, uniformly shaking, performing filtration by a sintered glass filter so as to obtain a solution, precisely measuring 2ml of the solution, putting the solution into a measuring bottle with the volume of 100ml, adding 1mg of neosigmine methylsuifate, adding water for dilution until a certain scale is reached, and uniformly shaking to obtain a suction reference solution; 2, precisely measuring 2ml of the neosigmine methylsuifate injection, putting the neosigmine methylsuifate injection into the measuring bottle with the volume of 100ml, adding the water for dilution until another certain scale is reached, and uniformly shaking to form a test product solution; and 3, injecting the suction reference solution and the test product solution into a liquid chromatograph for measurement. According to the detection method, the content of relevant substances can be detected.

Description

technical field [0001] The invention relates to a detection method, in particular to a detection method of neostigmine methylsulfate injection. Background technique [0002] Neostigmine Methosulfate Injection is a muscle relaxant, which is a special antidote for the treatment of myasthenia gravis and recovery of muscle relaxation after surgical anesthesia, especially for patients with myasthenia gravis who almost rely on this drug for survival. The existing detection method for Neostigmine Methosulfate Injection cannot detect the content of related substances. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a detection method for neostigmine methosulfate injection, which can detect the content of related substances. [0004] The present invention solves the problems of the technologies described above through the following technical solutions: a detection method for neostigmine methosulfate injection, character...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 陈良初
Owner SHANGHAI XINYI JINZHU PHARMA
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