Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cation-modified konjac glucomannan gellan gum microsphere as well as preparation method and application

A konjac polysaccharide and cation technology, which is applied in the field of biomedicine, can solve the problems of high preparation conditions, complicated preparation process, and high production cost, and achieve the effects of cost reduction, easy acquisition, and high cost solution

Inactive Publication Date: 2014-12-24
NANJING UNIV
View PDF1 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional drug delivery system has the disadvantages of complex preparation process, high requirements for preparation conditions, and relatively expensive equipment for preparation, resulting in high production costs.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cation-modified konjac glucomannan gellan gum microsphere as well as preparation method and application
  • Cation-modified konjac glucomannan gellan gum microsphere as well as preparation method and application
  • Cation-modified konjac glucomannan gellan gum microsphere as well as preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] During the implementation of the present invention, what mainly investigated is the synthesis of cationic konjac polysaccharides, the preparation of cKGM gellan gum microspheres containing nucleic acid drugs, and the ability of cKGM gellan gum microspheres to deliver nucleic acid drugs to the colon. The following are specific implementations process.

[0017] 1. Preparation of Cationic Konjac Polysaccharide

[0018] The synthetic method of the konjac polysaccharide of cationic modification: take the konjac polysaccharide of 500mg (purchased from Megazyme Company, Ireland) and dissolve in 25ml of Dimethicone (purchased from Sigma Company, the U.S.), prepare the dimethicone of the konjac polysaccharide of 20mg / ml A subalerene solution, then add 1.5g of CDI (purchased from Sigma, the U.S.) and stir at room temperature for 1 hour, then add 2.5ml of anhydrous ethylenediamine (purchased from Sigma, the U.S.), stir and react for 12 hours, and the reaction The liquid was trans...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of the biological medicine, and particularly relates to a cation-modified konjac glucomannan gellan gum microsphere as well as a preparation method and an application. The cation-modified konjac glucomannan gellan gum microsphere is prepared from a nucleic acid drug and a drug delivery carrier, wherein the nucleic acid drug is ribonucleic acid or desoxyribonucleic acid, and a drug delivery system comprises the components as follows: 20-30 parts of cKGM (cation konjac glucomannan), 1-9 parts of gellan gum and 0.01-6 parts of the nucleic acid drug. According to the microsphere, the requirement for colon-specific drug delivery of the oral microsphere is met, and the microsphere is simple in preparation technology and easy to industrialize and has very broad development and application prospects.

Description

1. Technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to konjac polysaccharide gellan gum microspheres modified with cations, a preparation method and application thereof. 2. Background technology [0002] Inflammatory bowel disease (Inflammatory bowel disease, IBD) is a chronic, easily relapsing gastrointestinal inflammatory disease. The etiology and pathogenesis of IBD are relatively complicated, and its diagnosis and treatment are quite difficult. It is difficult to completely cure it with existing treatment methods. life and health. In addition, colorectal cancer (CRC) is a malignant tumor of the digestive tract. In the world, CRC has become the third largest malignant tumor, and its morbidity and mortality are still on the rise. With the in-depth research on the pathogenesis of these gut-related diseases, small molecule inhibitors and antibodies targeting related disease-causing genes have been widely used. Nu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K48/00A61K47/36A61K9/16A61K49/00A61P1/00C08B37/00
Inventor 张峻峰董磊黄振
Owner NANJING UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com