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Efavirenz composition and preparation method thereof

A technology for efavirenz and a composition is applied in the field of efavirenz composition and its preparation, which can solve the problems of low oral bioavailability and achieve the effects of improving oral bioavailability, low cost and simple preparation method

Inactive Publication Date: 2014-12-24
SUZHOU PULUODA BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Efavirenz is a specific drug against HIV, but its oral bioavailability is low due to poor solubility in water

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Dissolve 0.1 g of hydroxyproline in 100 mL of ethanol, then add 0.1 g of sodium stearyl fumarate to obtain a dispersion of the auxiliary material; dissolve 0.1 g of efavirenz with 50 mL of ethanol to obtain a dispersion of the drug; Mix evenly with the drug dispersion, recover ethanol under vacuum at 40°C, and dry at 40°C for 6 hours to obtain the product.

Embodiment 2

[0014] Dissolve 0.1 g of hydroxyproline in 100 mL of ethanol, then add 0.1 g of sodium stearyl fumarate to obtain a dispersion of the auxiliary material; dissolve 0.1 g of efavirenz with 20 mL of ethanol to obtain a dispersion of the drug; Mix evenly with the drug dispersion, recover ethanol under vacuum at 40°C, and freeze-dry to obtain the product.

Embodiment 3

[0016] Dissolve 0.1 g of hydroxyproline in 200 mL of ethanol, then add 0.1 g of sodium stearyl fumarate to obtain a dispersion of the auxiliary material; dissolve 0.1 g of efavirenz with 100 mL of ethanol to obtain a dispersion of the drug; Mix evenly with the drug dispersion, recover ethanol under vacuum at 30°C, and freeze-dry to obtain the product.

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PUM

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Abstract

The invention provides an efavirenz composition with high orally-taken bioavailability and a preparation method for the efavirenz composition. The efavirenz composition is characterized by comprising efavirenz, sodium stearyl fumarate and hydroxyproline, wherein the mass ratio of efavirenz to sodium stearyl fumarate to hydroxyproline is preferably 1:1:1. The preparation method for the manidipine hydrochloride composition comprises the following steps: dissolving hydroxyproline with ethanol, and adding sodium stearyl fumarate to obtain auxiliary dispersion liquid; dissolving efavirenz with ethanol to obtain medicine dispersion liquid, uniformly mixing the auxiliary dispersion liquid and the medicine dispersion liquid, recycling ethanol, and drying to obtain the efavirenz composition.

Description

technical field [0001] The invention relates to an efavirenz composition and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Efavirenz is a specific drug against HIV, but its oral bioavailability is low due to its poor solubility in water. Contents of the invention [0003] The purpose of the present invention is to provide an efavirenz composition with high oral bioavailability and a preparation method thereof. [0004] For the purpose of the above invention, the present invention provides the following technical solutions: [0005] The efavirenz composition of the present invention is characterized in that it contains efavirenz, sodium stearyl fumarate and hydroxyproline; the mass ratio of efavirenz, sodium stearyl fumarate and hydroxyproline is preferably 1 :1:1. [0006] The method of the efavirenz composition of the present invention, its preparation steps are as follows: [0007] Dissolving hydroxyproline ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/536A61K9/19A61P31/18
Inventor 罗瑞雪
Owner SUZHOU PULUODA BIOLOGICAL SCI & TECH
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