A hollow zirconia nanomaterial with the functions of tumor microwave hyperthermia and CT imaging and its preparation method and application

A technology of microwave hyperthermia and zirconium dioxide, which is used in medical preparations containing active ingredients, wave energy or particle radiation treatment materials, anti-tumor drugs, etc., to achieve excellent microwave sensitization effect, good clinical application value, and good diagnosis. effect of treatment

Active Publication Date: 2016-08-10
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The multifunctional nanomaterial of the present invention has not yet been reported

Method used

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  • A hollow zirconia nanomaterial with the functions of tumor microwave hyperthermia and CT imaging and its preparation method and application
  • A hollow zirconia nanomaterial with the functions of tumor microwave hyperthermia and CT imaging and its preparation method and application
  • A hollow zirconia nanomaterial with the functions of tumor microwave hyperthermia and CT imaging and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Disperse 1-butyl-3-methylimidazolium tetrafluoroborate in deionized water with a volume fraction of 1%, and disperse evenly by ultrasonication or stirring;

[0040] (2) Add hollow zirconia nanomaterials to the 1-butyl-3-methylimidazolium tetrafluoroborate dispersion obtained in step 1), with a mass volume fraction of 1 mg mL -1 , sonicate for about 30 minutes under vacuum;

[0041] (3) The hollow zirconia nanomaterial loaded with 1-butyl-3-methylimidazolium tetrafluoroborate obtained in step 2) is sequentially washed with absolute ethanol and deionized water;

[0042] (4) The hollow zirconia nanomaterial obtained in step 3) has both CT enhancement and microwave sensitization properties, and is a multifunctional hollow nanomaterial.

[0043] from Figure 1-4 It can be clearly observed that the obtained hollow zirconia nanomaterials are uniformly distributed, the particle size distribution is narrow, the diameter is 350nm, and the shell thickness is 50nm, and it can...

Embodiment 2

[0049] (1) Disperse 1-butyl-3-methylimidazolium hexafluorophosphate in deionized water with a volume fraction of 10%, and disperse evenly by ultrasonication or stirring;

[0050] (2) Add hollow zirconia nanomaterials to the 1-butyl-3-methylimidazolium hexafluorophosphate dispersion obtained in step 1), with a mass volume fraction of 10 mg mL -1 , sonicate for about 60 minutes under vacuum;

[0051] (3) washing the hollow zirconia nanomaterials loaded with 1-butyl-3-methylimidazolium hexafluorophosphate obtained in step 2) with absolute ethanol and deionized water successively;

[0052] (4) The hollow zirconia nanomaterial obtained in step 3) has both CT enhancement and microwave sensitization properties, and is a multifunctional hollow nanomaterial.

[0053] The multifunctional hollow zirconia nanomaterial prepared in this example is used in microwave hyperthermia technology for tumors. The in vitro and in vivo microwave heating experiments and tumor hyperthermia effects are ...

Embodiment 3

[0058] (1) Disperse 1-butyl-3-methylimidazole L lactate in deionized water with a volume fraction of 3%, and disperse evenly by ultrasonication or stirring;

[0059] (2) Add hollow zirconia nanomaterials to the 1-butyl-3-methylimidazole L lactate dispersion obtained in step 1), and the mass volume fraction is 2 mg mL -1 , sonicate for about 40 minutes under vacuum;

[0060] (3) The hollow zirconia nanomaterials loaded with 1-butyl-3-methylimidazole L-lactate obtained in step 2) are washed with absolute ethanol and deionized water successively;

[0061] (4) The hollow zirconia nanomaterial obtained in step 3) has both CT enhancement and microwave sensitization properties, and is a multifunctional hollow nanomaterial.

[0062] The multifunctional hollow zirconia nanomaterial prepared in this example is used in microwave hyperthermia technology for tumors. The in vitro and in vivo microwave heating experiments and tumor hyperthermia effects are as follows:

[0063] Disperse the...

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Abstract

The invention discloses a multifunctional hollow zirconia nanometer material with the functions of microwave hyperthermia for tumors and CT imaging. The hollow nanometer material has a diameter of 50-1000nm and a shell thickness of 10-500nm. The multifunctional hollow zirconia nanometer material prepared by the invention has narrow particle size distribution, controllable shell thickness and size, and good dispersibility in both water and ethanol. In the present invention, the hollow zirconia nanomaterial is applied to the field of tumor microwave hyperthermia and CT imaging technology at the same time for the first time, which has achieved good treatment and imaging effects, greatly improved the efficiency of diagnosis and treatment, and at the same time can realize the goal of integration of diagnosis and treatment. Good clinical application value.

Description

technical field [0001] The invention relates to the field of hollow zirconia nanometer technology and its biological application. More specifically, it relates to a multifunctional hollow zirconia nanomaterial with functions of microwave hyperthermia for tumors and CT imaging, its preparation method and application. Background technique [0002] At present, the incidence of cancer is still on the rise worldwide, and the status of cancer is not optimistic (Nanoscale, 2012, 4, 330-342, Nanoscale, 2013, 5, 12409-12424). In 2013, the number of new cancer cases in the world was more than 14 million, and it is expected to rise to more than 20 million by 2030. For my country, one person is diagnosed with cancer every 6 minutes in the whole country, 8550 people become cancer patients every day, about 22% of people suffer from cancer, and one person dies of cancer in every 7-8 people, the cumulative rate (0 ~74 years old) is 12.94% for Chinese residents to die from cancer. Due to v...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K49/04A61P35/00
Inventor 孟宪伟史海堂谭龙飞
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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