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Comprehensive model for protecting mice and curing mice macrophage system UC (Ulcerative Colitis) by C-BF (Cathelicidin-BF)

A technology for ulcerative colitis and macrophages, applied in the field of biomedicine

Inactive Publication Date: 2014-12-10
ZHEJIANG UNIV
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Problems solved by technology

So far, research on other potential biomedical functions caused by the non-antibacterial activity mechanism of C-BF is still blank

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  • Comprehensive model for protecting mice and curing mice macrophage system UC (Ulcerative Colitis) by C-BF (Cathelicidin-BF)
  • Comprehensive model for protecting mice and curing mice macrophage system UC (Ulcerative Colitis) by C-BF (Cathelicidin-BF)
  • Comprehensive model for protecting mice and curing mice macrophage system UC (Ulcerative Colitis) by C-BF (Cathelicidin-BF)

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Embodiment Construction

[0028]The present invention will be described in detail below in conjunction with the accompanying drawings, and the embodiments are only for describing but not limiting the present invention.

[0029] 1. We first confirmed that the antimicrobial peptide C-BF can be absorbed by the peritoneum by using in vivo imaging technology, but it is completely metabolized after remaining in the body for 24 hours. figure 1 In order to confirm the absorption of antimicrobial peptide C-BF into the intestinal cavity by using in vivo imaging technology; from figure 1 We can confirm that C-BF spreads from the intestinal cavity to the whole body in about 10 minutes, but C-BF is metabolized or excreted in the body within 24 hours, so each injection of C-BF should not exceed 24 hours;

[0030] 2. On this basis, we established a 3% DSS-induced ulcerative colitis model in mice, and the experimental grouping and design were as follows: figure 2 :

[0031] C-BF dose: 5mg / kg mouse body weight, the ...

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Abstract

The invention discloses a comprehensive model for protecting mice and curing mice macrophage system UC (Ulcerative Colitis) by C-BF (Cathelicidin-BF). C-BF has broad-spectrum antibacterial activity, especially for gram-negative bacteria. IBDS (Inflammatory Bowel Diseases) include UC and CD (Crohn's Disease), and the pathological mechanisms of IBDS are not clear. The comprehensive model provided by the invention combines in-vivo mice experiments and in-vitro cell experiments to evaluate the effects of C-BF on relieving inflammations, reducing the cell apoptosis level and improving the intestinal barrier function.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the protective effect of C-BF antimicrobial peptide on UC mice. Background technique [0002] IBD is the abbreviation of inflammatory bowel disease, including ulcerative colitis and Crohn's disease, and its pathological mechanism is still unclear. IBD is defined as chronic relapsing gastrointestinal inflammation. Recent studies have shown that various immune, genetic and environmental factors affect the initiation and progression of colitis. The incidence of IBD is higher in Western countries, however, the incidence of IBD in other parts of the world is also increasing due to the influence of Western lifestyle. Ulcerative colitis is a chronic gastrointestinal disease associated with inflammation of the colonic mucosal surface. Human infection with ulcerative colitis may transform into the third most malignant tumor in humans—colorectal cancer. [0003] There are two majo...

Claims

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Application Information

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IPC IPC(8): C12N5/0786A01K67/027A61D7/00
Inventor 汪以真张海文戎亦骊
Owner ZHEJIANG UNIV
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