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Sugar-free zinc lysine granule composition and preparation method

A technology of zinc lysine and its composition, which is applied in the field of medicine, and can solve problems such as uneven packaging and inclusion, low particle hardness, and poor compliance of children and patients

Active Publication Date: 2016-10-26
厦门康艺迈医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

First, the high content of sucrose makes lysine hydrochloride and zinc gluconate granules not suitable for diabetic patients; it also makes non-diabetic patients consume unnecessary high energy; second, the proportion of raw and auxiliary materials is too large, which is easy to cause The content between packages is uneven; third, the hardness of the particles is not high, and they are easy to be crushed during packaging and transportation
Fourth, the fluidity is not good, and the filling volume varies greatly. Fifth, there is no flavor in the granules, the taste is not good, and the compliance of children is poor.

Method used

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  • Sugar-free zinc lysine granule composition and preparation method
  • Sugar-free zinc lysine granule composition and preparation method
  • Sugar-free zinc lysine granule composition and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0133] Embodiment 1: preparation zinc lysine gluconate granule composition

[0134] formula:

[0135]

[0136] Preparation method:

[0137] (1) dissolving citric acid in an appropriate amount of water (the amount of water is 90 times the weight of citric acid), then adding zinc gluconate and lysine hydrochloride successively and dissolving it to obtain a clear solution;

[0138] (2) Adjust an appropriate amount of starch (accounting for 50% of the prescription amount) into a paste with 2 times the weight of water, then mix it evenly with the solution obtained in step (1), stir and heat up to 70° C. to obtain solution I, spare;

[0139] (3) Make the remaining amount of starch into a paste with 8 times the weight of water, stir and heat up to 70°C at the same time to obtain solution II, which is set aside;

[0140] (4) Put the prescribed amount of mannitol into the fluidized bed granulator, mix for 5 minutes, turn on the heating to 70°C, spray into solution I, and then s...

Embodiment 2

[0143] Embodiment 2: preparation zinc lysine gluconate granule composition

[0144] formula:

[0145]

[0146] Preparation method:

[0147] (1) dissolving citric acid in an appropriate amount of water (the amount of water is 80 times the weight of citric acid), then adding zinc gluconate and lysine hydrochloride successively and dissolving them to obtain a clear solution;

[0148] (2) Adjust an appropriate amount of starch (accounting for 60% of the prescription amount) into a paste with 2 times the weight of water, then mix evenly with the solution obtained in step (1), stir and heat up to 65° C. to obtain solution I, spare;

[0149] (3) Make the remaining amount of starch into a paste with 6 times the weight of water, stir and heat up to 75°C at the same time to obtain solution II, which is set aside;

[0150] (4) Put the prescribed amount of mannitol into the fluidized bed granulator, mix for 5 minutes, turn on the heating to 65°C, spray into solution I, and then sp...

Embodiment 3

[0153] Embodiment 3: preparation zinc lysine gluconate granule composition

[0154] formula:

[0155]

[0156] Preparation method:

[0157] (1) dissolving citric acid in an appropriate amount of water (the amount of water is 110 times the weight of citric acid), then adding zinc gluconate and lysine hydrochloride successively and dissolving it to obtain a clear solution;

[0158] (2) Adjust an appropriate amount of starch (accounting for 40% of the prescription amount) into a paste with 2 times the weight of water, then mix it evenly with the solution obtained in step (1), stir and heat up to 75° C. to obtain solution I, spare;

[0159](3) Make the remaining amount of starch into a paste with 10 times the weight of water, stir and heat up to 75°C at the same time to obtain solution II, which is set aside;

[0160] (4) Put the prescribed amount of mannitol into the fluidized bed granulator, mix for 5 minutes, turn on the heating to 75°C, spray into solution I, and then ...

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Abstract

The invention relates to a sugar-free zinc lysine granule composition and a preparation method. The invention belongs to the technical field of medicine, relates to a composition for supplementing lysine and zinc, especially zinc gluconate, in particular to a granule for supplementing lysine and zinc, especially zinc gluconate, more particularly The invention relates to a sugar-free granule for supplementing lysine and zinc, especially zinc gluconate. The invention also relates to a method for preparing said composition. The zinc lysine granule provided by the invention is a mineral non-prescription medicine. It is clinically used to prevent growth retardation, malnutrition and anorexia caused by lack of lysine and zinc in children and adolescents. Lysine Glucose Zinc Granules contain lysine, which is one of the essential amino acids to maintain the nitrogen balance of the human body, and has the effect of promoting human growth; zinc is an important component of various enzymes in the body, which can promote growth and improve taste.

Description

technical field [0001] The invention belongs to the technical field of medicine, relates to a composition for supplementing lysine and zinc, especially zinc gluconate, in particular to a granule for supplementing lysine and zinc, especially zinc gluconate, more particularly The invention relates to a sugar-free granule for supplementing lysine and zinc, especially zinc gluconate. The invention also relates to a method for preparing said composition. Background technique [0002] Lysine, also known as L-lysine hydrochloride, is an essential amino acid. The English name of lysine is lysine, the abbreviation is Lys, the single-letter abbreviation of amino acid is K, and its chemical formula is H 2 NCH 2 CH 2 CH 2 CH 2 CH(NH 2 )COOH, molecular formula: C 6 h 14 N 2 o 2 , molecular weight 146.19, CAS No. 56-87-1, chemical structural formula: [0003] [0004] Symptoms of lysine deficiency include fatigue, weakness, nausea, vomiting, dizziness, loss of appetite, dev...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/315A61K9/16A61K47/36A61P3/02A61P1/14
Inventor 郑敬操
Owner 厦门康艺迈医药科技有限公司
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