Lignan glycoside compounds and preparation method thereof

A technology for compounds and compound structural formulas, applied in the field of 8,4'-oxyneolignan glycosides and their preparation, can solve the problems of lack of research on nerve cell protection activity, lack of research on dendrobium lignan glycosides, etc. Effectiveness in the treatment of neurodegenerative diseases

Active Publication Date: 2014-11-19
SICHUAN WANAN DENDROBIUM IND DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the deepening of people's understanding of Dendrobium and the advancement of modern science and technology, the research on the medicinal parts and active ingredients of Dendrobium has been carried out rapidly, but there are few studies on Dendrobium lignansides, and the research on the activity of nerve cell protection is very limited. lack

Method used

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  • Lignan glycoside compounds and preparation method thereof
  • Lignan glycoside compounds and preparation method thereof
  • Lignan glycoside compounds and preparation method thereof

Examples

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Embodiment 1

[0044] Example 1 (–)-(7S,8R,7′E)-4-hydroxyl-3,3′,5,5′-tetramethoxy-8,4′-oxyneolicane-7′- Extraction, purification and structure identification of ene-7,9,9′-triol 7,9′-bis-O-β-D-glucoside

[0045] (1) Experimental materials:

[0046] ① Medicinal materials

[0047]Dendrobium was collected from Shuangliu, Chengdu, Sichuan, and provided by Sichuan Wanan Dendrobium Company. It was identified as the stem of Dendrobium aurantiacum var.

[0048] ②Reagents and fillers

[0049] Column chromatography silica gel, 200-300 mesh (reagent grade), purchased from Qingdao Haiyang Silica Gel Desiccant Factory;

[0050] TLC silica gel G, GF 254 and H (chemically pure), purchased from Qingdao Haiyang Silica Gel Desiccant Factory;

[0051] Sephadex LH-20 glucan gel, purchased from Sweden Amersham company;

[0052] GF 254 Silica gel preparation thin layer, purchased from Yantai Jiangyou Silica Gel Development Co., Ltd.;

[0053] Chromatographic methanol, 4L / bottle, was purchased from Fisher ...

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Abstract

The present invention provides a compound as represented by formula I, which has a structure as follows: R1 and R2 are glycosyl, R3 is H, hydroxyl or methoxyl; R4 is hydroxyl or methoxyl; and R5 is H, hydroxyl or methoxyl. The present invention further provides a preparation method and purpose of the compound. In the present invention, 8,4'-oxyl neolignan glycoside compound is obtained from dendrobium nobile, inhibits PC12 cell neurotoxicity caused by glutamic acid, protects nerve cells in certain degree, and can be used for treatment of neurodegenerative disorder.

Description

technical field [0001] The invention relates to an 8,4'-oxygenoidin glycoside compound and a preparation method thereof. Background technique [0002] Dendrobium is the largest genus in Orchidaceae, including about 1100 species of plants, mainly distributed in tropical Asia and Pacific islands. There are about 63 species of Dendrobium plants in China, and 39 species of Dendrobium plants for medicinal purposes. From a vertical point of view, there are distributions at altitudes ranging from 100 to 3,000 meters above sea level. Medicinal Dendrobium is mostly harvested in autumn, dried and cut into sections, or used fresh. Sweet in the mouth, slightly cold in nature. Can nourish yin and clear away heat, benefit stomach and promote body fluid. It is used for heat-injured body fluid, low fever and polydipsia, red tongue with little coating; deficiency of stomach yin, thirsty and dry throat, vomiting and less food, dull pain in epigastric cavity, light tongue with little coati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/18C07H1/08A61K31/7032A61P25/00
CPCA61P25/00A61P25/28C07H1/08C07H15/18
Inventor 郭力熊亮张廷模李小红郭一平韩瑜
Owner SICHUAN WANAN DENDROBIUM IND DEV
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