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Bending fully degradable magnesium alloy nerve guide and its preparation method

A nerve conduit and magnesium alloy technology are applied in the field of bendable and fully degradable magnesium alloy nerve conduits and their preparation. The invention can solve the problems of inflexibility of magnesium alloy nerve conduits, uncomfortable nerve repair, and the like, achieve the realization time and conduit degradation time, and inhibit bacteria. Excellent growth and biocompatibility

Active Publication Date: 2016-09-07
SHANGHAI INNOVATON MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the magnesium alloy nerve guide prepared by the above process method cannot be bent, and is not suitable for the repair of nerves that need to be bent in joints and other parts.

Method used

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  • Bending fully degradable magnesium alloy nerve guide and its preparation method
  • Bending fully degradable magnesium alloy nerve guide and its preparation method

Examples

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preparation example Construction

[0043] The above-mentioned bendable fully degradable magnesium alloy nerve guide and its preparation method comprise the following steps:

[0044]Step 1, passing the initial magnesium alloy billet through an extrusion die to obtain a thick magnesium alloy wire;

[0045] Step 2, drawing the magnesium alloy thick wire obtained in step 1 through multiple passes to obtain a magnesium alloy wire of the final required size;

[0046] Step 3, performing stress relief annealing on the magnesium alloy wire obtained in step 2;

[0047] Step 4, polishing the magnesium alloy wire obtained in step 3;

[0048] Step 5, braiding the magnesium alloy wire obtained in step 4 to form a bendable fully degradable magnesium alloy nerve guide.

[0049] Further, in step 1, the outer diameter of the magnesium alloy initial billet is Φ20mm, and the length is 30mm; the extrusion temperature is 300-400°C; the size of the magnesium alloy thick wire is Φ1-3mm; Lubricant is sprayed between the extrusion di...

Embodiment 1

[0056] This embodiment relates to a flexible fully degradable magnesium alloy nerve guide for nerve defect repair, its structure is as follows figure 1 As shown, the length is 5mm, the outer diameter is 1mm, and the wall thickness is 0.10mm. The nerve guide is braided by filaments with a diameter of 0.05 mm, the distance between two adjacent rows of filaments in the same direction is 0.005 mm, and the braiding angle between each row of filaments and the tube axis is 45 degrees.

[0057] This embodiment relates to the aforementioned method for preparing a degradable magnesium alloy nerve guide for repairing nerve defects, and the shown method includes the following steps:

[0058] In step 1, the initial billet of Mg-Nd-Zn-Zr magnesium alloy with an outer diameter of 20mm and a length of 30mm is extruded at a temperature of 350°C to obtain Magnesium alloy thick wire;

[0059] Step 2, will Magnesium alloy thick wire with a diameter of 0.05mm is obtained after multi-pass draw...

Embodiment 2

[0064] This embodiment relates to a flexible fully degradable magnesium alloy nerve guide for nerve defect repair, its structure is as follows figure 1 As shown, the length is 100mm, the wall thickness is 0.40mm, and the outer diameter is 10mm. The nerve guide is braided by filaments with a diameter of 0.2 mm, the distance between two adjacent rows of filaments in the same direction is 0.05 mm, and the braiding angle between each row of filaments and the tube axis is 45 degrees.

[0065] This embodiment relates to the aforementioned method for preparing a degradable magnesium alloy nerve guide for repairing nerve defects, and the shown method includes the following steps:

[0066] Step 1, extruding the initial Mg-Zn-Zr magnesium alloy blank with an outer diameter of 20mm and a length of 30mm at a temperature of 300°C to obtain a thick magnesium alloy wire of Φ3mm;

[0067] Step 2, drawing the Φ3mm magnesium alloy thick wire through multiple passes to obtain a magnesium alloy ...

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Abstract

The present invention provides a bendable and fully degradable magnesium alloy nerve guide for nerve defect repair, which forms an integrally formed round tubular structure through the braiding of multiple magnesium alloy wires, wherein the distance between each row of magnesium alloy wires and the shaft of the round tube is There is a 45-degree angle between them, and there is a gap between two adjacent rows of magnesium alloy wires in the same direction; meanwhile, a preparation method for the bendable fully degradable magnesium alloy nerve guide is provided. The bendable fully degradable magnesium alloy nerve guide provided by the invention has high radial support strength, good bending flexibility, and controllable uniform degradation performance. The prepared bendable fully degradable magnesium alloy nerve conduit for nerve defect repair has uniform wall thickness and smooth surface, and can be widely used to repair various defective nerves that need to be bent.

Description

technical field [0001] The invention relates to the technical field of biological material processing, in particular to a bendable fully degradable magnesium alloy nerve guide for repairing nerve defects and a preparation method thereof. Background technique [0002] The repair materials for peripheral nerve defects include autologous tissues (such as nerves, blood vessels, acellular matrix, etc.), but the sources of autologous tissues are limited and will cause permanent damage to the donor site. Bridging and repairing nerve defects through catheter-based tissue-engineered artificial nerves is the most promising approach. At present, the catheters used in nerve repair mainly focus on high molecular polymers and natural biomaterials (such as collagen, etc.). The poor wall permeability makes it difficult to precisely control the degradation time, which is not conducive to the regeneration of nerve axons. Therefore, no ideal nerve guide material has been widely used clinical...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/04A61L27/04A61L27/50
Inventor 袁广银丁文江
Owner SHANGHAI INNOVATON MEDICAL TECH CO LTD
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