Fabrication method of microneedle array based on high voltage electric field

Abstract

The invention relates to the technical field of biomedical engineering, in particular to a high voltage electric field-based manufacturing method for a microneedle array. The speed, flowing into a substrate die, of a substrate mixture solution is controlled by arranging a push injection device, and the substrate mixture solution is uniformly distributed on the substrate die, and is prevented from being accumulated; the substrate mixture solution is enabled to form a taylor cone, namely a microneedle array structure, on a hole die by using the mutual action between the electric field generated by an electric field generation device and the substrate mixture solution through controlling the voltage size, the manufacturing cost of the micronedle array structure is reduced, and the manufacturing method of the micronedle technology is simple and easy to operate.

Description

technical field [0001] The present invention relates to the technical field of a biomedical engineering method, and more specifically, to a method for manufacturing a microneedle array based on a high-voltage electric field. Background technique [0002] In the field of medical treatment, although biotechnology has produced many mature and effective drugs, the delivery of many drugs is subject to some restrictions, the most obvious being the oral administration of drugs and the injection of drugs. [0003] The main problem with oral administration is the degradation of the drug in the gastrointestinal tract and the excretion of the drug through the liver. Another commonly used way of administration is through intravenous injection. This method is not easy to use in non-medical places, and it is not easy to maintain and control the release of drugs, and it is inconvenient and painful for patients. Delivery of drugs through the skin is an attractive new approach, but this app...

AI Technical Summary

Problems solved by technology

However, due to the high cost of synchronous X-rays and the long production cycle, the cost of making microneedles with LIGA technology is very high, and the process is complicated and difficult to control.

[0006] The early microneedles mainly used silicon as the material. Due to the defects of low mechanical strength, high brittleness, easy fracture, unclear biocompatibility with the human body, and high processing costs, the conditions and conditions for promotion are not available at this stage. potential

In addition to significant advantages in physical and mechanical properties and mechanical properties, metal microneedles still have certain deficiencies in biocompatibility, and the processing process is relatively complicated. The obtained metal microneedles have certain difficulties in drug loading and drug release. , the effect is not necessarily ideal

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