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Application of kaempferol in preparation of medicines for preventing and treating radiation-induced pulmonary injury

A technology for radiation-induced lung injury and kaempferol, which is applied to preparations made from kaempferol as a drug raw material. The application field of kaempferol in the prevention and treatment of radiation-induced lung injury can solve the unfavorable long-term use of kaempferol and prevent and treat radiation-induced lung injury. Injury effect and other problems, to improve inflammatory exudation, expand the effect of application

Inactive Publication Date: 2014-09-03
SHANDONG RES INST OF TUMOUR PREVENTION TREATMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are relatively few drugs for the treatment of radiation-induced lung injury, and the more commonly used therapeutic agents are hormones, which can suppress immunity and are not conducive to long-term use
However, there is no report on the effect of kaempferol on the prevention and treatment of radiation-induced lung injury.

Method used

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  • Application of kaempferol in preparation of medicines for preventing and treating radiation-induced pulmonary injury
  • Application of kaempferol in preparation of medicines for preventing and treating radiation-induced pulmonary injury
  • Application of kaempferol in preparation of medicines for preventing and treating radiation-induced pulmonary injury

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Experimental program
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Effect test

Embodiment Construction

[0020] The radiation protection effect of kaempferol is studied through animal experiments. Kaempferol and formononetin used in the present invention can be bought in the market.

[0021] Animal Experimental Study on Radiation Protection Effect of Kaempferol

[0022] 1. Preparation of reagents used

[0023] (1) Kaempferol solution: take 100mg kaempferol, dissolve it in 25ml of a mixed solvent of DMSO, propylene glycol, PEG400 and 5wt% F68 with a volume ratio of 1:2:2:5, and configure it into a 4mg / ml solution, avoiding Store light in a 4°C refrigerator.

[0024] (2) Amifostine solution: Take 10 mg of amifostine, dissolve it in 2.5 ml of normal saline, and prepare a 4 mg / ml amifostine solution, which is prepared and used immediately.

[0025] (3) Pentobarbital sodium solution: Take 100mg of pentobarbital sodium, dissolve it in 10ml of normal saline, and prepare a 1wt% pentobarbital sodium solution, which is prepared and used immediately.

[0026] 2. Experimental method ...

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Abstract

The invention discloses application of kaempferol in preparation of medicines for preventing and treating radiation-induced pulmonary injury. The experiment proves that kaempferol can obviously improve inflammatory exudation of lung tissues suffering from the mouse radiation-induced pulmonary injury and has an excellent positive effect on the radiation-induced pulmonary injury. The invention provides a novel drug for radiation-induced pulmonary injury diseases. A novel thought is provided for research and development of medicines for treating the radiation-induced pulmonary injury, and the application path of kaempferol in the field of medicines is widened.

Description

technical field [0001] The invention relates to a new application of kaempferol, in particular to the application of kaempferol in medicines for preventing and treating radiation-induced lung injury, and a preparation prepared by using kaempferol as a raw material of the medicine. Background technique [0002] Radiation lung injury (radio-pulmonary lesion) is a complication caused by radiation therapy for malignant tumors of the chest. Due to the difference in radiation dose, radiation site and radiation range, the severity of lung injury varies, and severe pulmonary interstitial fibrosis will form. When lung injury occurs, the current approach is to stop radiotherapy or treat symptoms. At present, there are relatively few drugs for the treatment of radiation-induced lung injury. The more commonly used therapeutic agents are hormones, which can suppress immunity and are not conducive to long-term use. Therefore, it is necessary to develop new effective therapeutic drugs. ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P11/00
Inventor 李宝生付成瑞郭斌徐恒卫
Owner SHANDONG RES INST OF TUMOUR PREVENTION TREATMENT
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