Coronary artery dilating catheter carrying ligustrazine nanoparticles

Abstract

The invention discloses a coronary artery dilating catheter carrying ligustrazine nanoparticles. The coronary artery dilating catheter is characterized by comprising a sharp end, a guide wire channel, a far end part of the catheter, a sacculus of which the outer surface carries the ligustrazine nanoparticles, a near end part of the catheter, a side hole and a replenishing device, wherein the sharp end is connected to the guide wire channel and is communicated with the side hole; one end of the sacculus is fixed to the guide wire channel; the other end of the sacculus is connected to the far end part of the catheter; the side hole is located in the far end part of the catheter outside the sacculus; the far end part of the catheter is connected to the near end part of the catheter; the near end part of the catheter is connected to the replenishing device; the guide wire channel, the far end part of the catheter and the sacculus are not communicated. During dilation, ligustrazine nanoparticle medicines on the coronary artery dilating catheter can directly contact the inner coronary artery plaque, and the resistance is reduced; meanwhile, compared with dilating catheters of other medicines, the coronary artery dilating catheter carrying the ligustrazine nanoparticles has the advantages that the drug toxicity of the ligustrazine nanoparticle medicines is smaller, and the price is low.

Description

technical field [0001] The invention relates to a medical device, in particular to a coronary artery dilation catheter carrying ligustrazine nanoparticles. Background technique [0002] Coronary atherosclerotic heart disease is a heart disease caused by atherosclerotic lesions in the coronary arteries that cause stenosis or blockage of the vessel lumen, resulting in myocardial ischemia, hypoxia or necrosis. It is often called "coronary heart disease". [0003] At present, percutaneous transluminal coronary angioplasty (PTCA) is a new method for the treatment of coronary heart disease. It is based on the Seldinger technique that appeared in the early 1970s, specifically a percutaneous puncture The arterial vascular balloon catheter is retrogradely inserted into the coronary atherosclerotic plaque, and then the balloon is filled with diluted contrast agent, and the plaque is compressed and broken by the extrusion of the balloon, so that the narrow coronary artery cavity become...

AI Technical Summary

Problems solved by technology

However, the drug loaded on the drug-coated balloon is generally paclitaxel and other western medicines, and the toxicity and side effects of the drug are relatively large, such as allergic reactions, late aneurysm formation, etc.

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