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Preparation methods of drug for promoting bone morphogenetie protein expression to accelerate fracture healing

A protein expression and fracture healing technology, which is applied in the preparation of sugar derivatives, medical preparations containing active ingredients, and drug combinations, can solve problems such as non-union and delayed fracture healing, and achieve a simple preparation method and a wide source of raw materials. Effect

Inactive Publication Date: 2014-07-23
广州噢斯荣医药技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A variety of methods to promote fracture healing have been applied clinically, but the problems of delayed fracture union and nonunion have not been completely resolved

Method used

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  • Preparation methods of drug for promoting bone morphogenetie protein expression to accelerate fracture healing
  • Preparation methods of drug for promoting bone morphogenetie protein expression to accelerate fracture healing
  • Preparation methods of drug for promoting bone morphogenetie protein expression to accelerate fracture healing

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Carboxymethylation preparation: add 15g (2mol / L) sodium hydroxide liquid 380-400ml per 100g sodium alginate, mix well, stir at 35°C for 0.5h; then add 20g monochloroacetic acid per 100g sodium alginate The mixture with 20g of sodium hydroxide was stirred and reacted at 70-80°C for 3h, the reaction product was washed with 95% ethanol, and precipitated for 24h to obtain carboxymethyl sodium alginate product, which was dried.

[0029] The mass ratio of sodium hydroxide to sodium alginate is 0.35-0.4:1.0; the mass ratio of chloroacetic acid to sodium alginate is 0.2:1.0.

Embodiment 2

[0031] One-pot frying method: Take sodium alginate, sodium hydroxide, and monochloroacetic acid according to mass: mass: volume = 1: 0.35: 0.30, put them into 2 times the volume of ethanol solution with a volume fraction of 95%, and put them at the etherification temperature The reaction was carried out at 50°C and the etherification time was 3h. The reaction product was washed with 95% ethanol, precipitated for 24 hours, and the product was dried to obtain carboxymethyl sodium alginate product.

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Abstract

A drug for promoting bone morphogenetie protein expression to accelerate fracture healing is prepared by carboxymethylation of sodium alginate. The drug is prepared by the steps: adding 15 g of a sodium hydroxide liquid (2 mol / L) into each 100 g of sodium alginate, mixing uniformly, and stirring for 0.5 h at the temperature of 35 DEG C; then adding a mixture of 20 g of monochloroacetic acid and 20 g of sodium hydroxide according to each 100 g of sodium alginate, carrying out a stirring reaction for 3 h under a condition of the temperature of 70-80 DEG C, and thus obtaining a carboxymethyl sodium alginate resultant. The drug also can be prepared by in a 95% ethanol solution, taking sodium alginate, sodium hydroxide and monochloroacetic acid and carrying out a one-pot frying method, and particularly is prepared by the steps: according to the ratio of mass, mass and volume of 1:0.35:0.30, taking sodium alginate, sodium hydroxide and monochloroacetic acid, putting into the 95 vol% ethanol solution with the volume of 2 times that of the mixture, and carrying out a reaction under conditions of the etherification temperature of 50 DEG C and the etherification time of 3 h; and washing the reaction product with 95% ethanol, precipitating for 24 h, drying the resultant, and thus obtaining the carboxymethyl sodium alginate resultant. The obtained carboxymethyl sodium alginate is capable of promoting the bone morphogenetie protein expression, and is used in drugs for treating and preventing fractures, bone nonunion, osteonecrosis of the femoral head, and osteoporosis.

Description

technical field [0001] The invention belongs to medical clinical medicine, and in particular relates to a medicine suitable for the treatment and prevention of fracture, nonunion, femoral head necrosis and osteoporosis. Background technique [0002] With the development of society, the prosperity of the transportation industry, and the frequent development of various sports, various traumas and fractures have become common clinical diseases and frequently-occurring diseases, seriously endangering human health and affecting people's ability to work. How to promote fracture healing as soon as possible is a key topic in the field of orthopedics and traumatology. [0003] Fracture healing is an extremely complex biological repair process. Various methods to promote fracture healing have been applied clinically, but the problems of delayed fracture union and nonunion have not been completely resolved. In recent years, due to the development and application of gene technology, p...

Claims

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Application Information

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IPC IPC(8): C08B37/04C07H15/04C07H1/00A61P19/08A61P19/10
CPCA61K31/734C08B37/0084
Inventor 姬明丽黄锋杨宇平杜鹏程王天宝
Owner 广州噢斯荣医药技术有限公司
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