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Medicine for treating wegner granulomatosis combined with pseudotumot of orbit and preparation method thereof

A technology of Wegener's granulomatosis and drugs, which is applied in the field of medicine and can solve problems that have not been reported

Inactive Publication Date: 2014-07-09
滨州医学院附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there is no report that there is a specific drug for Wegener's granulomatosis combined with intraorbital pseudotumor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Angelica 1000g, Licorice 500g, Shuanghua 1500g, Yuanshen 1500g, Tribulus terrestris 200g, Prunella vulgaris 500g.

[0023] Preparation:

[0024] a. Add Chinese angelica, licorice root, root ginseng, tribulus terrestris and Prunella vulgaris to decoct for two times, add water 5 times the volume of the medicine for the first time and decoct for 2 hours, add water 3 times the volume of the medicine for the second time and decoct 1.5 hours, combine the decoctions, and filter; the filtrate is concentrated at 60°C to a concentrated solution with a relative density of 1.22 to 1.26, let it cool, add ethanol until the alcohol content reaches 80%, stir well, stand at room temperature for 12 hours, and filter; Recover ethanol at 60°C and concentrate to a thick paste with a relative density of 1.35-1.38;

[0025] b. add honey and water to the thick paste prepared in step a to make ointment, and prepare 1000g altogether.

[0026] Usage and dosage: 50g each time, 2-3 times a day, 1...

Embodiment 2

[0028] Angelica 900g, Licorice 550g, Shuanghua 1400g, Yuanshen 1600g, Tribulus terrestris 180g, Prunella vulgaris 550g.

[0029] Preparation:

[0030] a. Add Chinese angelica, licorice root, root ginseng, tribulus terrestris, and Prunella vulgaris to decoct for two times, add 4 times the volume of the drug for the first time and decoct for 1.5 hours, add 2 times the volume of the drug for the second time and decoct for 1 hours, combine the decoctions, and filter; the filtrate is concentrated at 60°C to a concentrated solution with a relative density of 1.22 to 1.26, let it cool, add ethanol until the alcohol content reaches 80%, stir well, stand at room temperature for 12 hours, and filter; Recover ethanol at 60°C and concentrate to a thick paste with a relative density of 1.35-1.38;

[0031] b. Add honey and water to the thick paste prepared in step a to make granules, and prepare 1000g altogether.

[0032] Usage and dosage: 50g each time, 2-3 times a day, 10 days as a cour...

Embodiment 3

[0034] Angelica 1000g, Licorice 450g, Shuanghua 1600g, Yuanshen 1400g, Tribulus terrestris 220g, Prunella vulgaris 450g.

[0035] Preparation:

[0036] a. Add Chinese angelica, licorice root, root ginseng, tribulus terrestris, and Prunella vulgaris to decoct for two times, add 6 times the volume of medicine for the first time and decoct for 2.5 hours, add water for 5 times the volume of medicine for the second time and decoct for 2 hours, combine the decoctions, and filter; the filtrate is concentrated at 60°C to a concentrated solution with a relative density of 1.22 to 1.26, let it cool, add ethanol until the alcohol content reaches 80%, stir well, stand at room temperature for 12 hours, and filter; Recover ethanol at 60°C and concentrate to a thick paste with a relative density of 1.35-1.38;

[0037] b. add honey and water to the thick paste prepared in step a to make ointment, and prepare 1000g altogether.

[0038] Usage and dosage: 50g each time, 2-3 times a day, 10 day...

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Abstract

The invention belongs to the technical field of medicines and particularly relates to a medicine for treating wegner granulomatosis combined with pseudotumot of orbit and a preparation method thereof. The medicine for treating wegner granulomatosis combined with pseudotumot of orbit is prepared from the following traditional Chinese medicine raw material medicines in parts by weight: 80-120 parts of angelica sinensis, 40-60 parts of liquorice, 130-170 parts of double blossom, 130-170 parts of radix scrophulariae, 16-24 parts of caltrop and 40-60 parts of selfheal. The total remission rate of the medicine for treating wegner granulomatosis combined with pseudotumot of orbit is 62%.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medicine for treating Wegener's granulomatosis combined with intraorbital pseudotumor and a preparation method thereof. Background technique [0002] Wegener granulomatosis (Wegener granulomatosis, WG) is a systemic, necrotizing, granulomatous vasculitis involving small and medium blood vessels. Various, the typical triad is upper, lower respiratory tract and kidney lesions; eye involvement is more common, 50% to 60%, any area of ​​the eye can be involved, 15% to 20% can invade the orbit and manifest as exophthalmos, Intraorbital pseudotumor. If the cause of intraorbital pseudotumor cannot be identified early and the treatment is delayed, it may cause serious ocular complications, such as loss of vision and removal of the eyeball. . [0003] So far, there is no report that there is a drug dedicated to Wegener's granulomatosis combined with intraorbital pseudotum...

Claims

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Application Information

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IPC IPC(8): A61K36/808A61P29/00A61P9/14
Inventor 王滨满玉清边瑞民崔光怀张循格
Owner 滨州医学院附属医院
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