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Pharmaceutical composition of cerebrolysin vial for injection

A brain protein hydrolyzate and protein hydrolyzate technology, applied in the field of pharmaceutical preparations, can solve the problems of high technical total nitrogen content, complex operation process, and low output

Active Publication Date: 2014-07-02
GUANGDONG LONGFU MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation methods of cerebroprotein hydrolyzate injection powder in these prior art have problems such as long production cycle, low output, complex operation process, and high technical total nitrogen content requirements.

Method used

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  • Pharmaceutical composition of cerebrolysin vial for injection
  • Pharmaceutical composition of cerebrolysin vial for injection
  • Pharmaceutical composition of cerebrolysin vial for injection

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0080]

[0081] A pharmaceutical composition of cerebroprotein hydrolyzate for injection, taking an appropriate amount of water for injection, slowly adding cerebroprotein hydrolyzate under stirring at 500rp / min until completely dissolved, slowly adding 4-aminobutyric acid until completely dissolved under stirring at 500rp / min Dissolve, slowly add mannitol under stirring at 500rp / min until completely dissolved, take an appropriate amount of pH regulator (disodium hydrogen phosphate-sodium dihydrogen phosphate) to adjust the pH of the solution within the range of 7.0, stir at room temperature, centrifuge, and take the supernatant , add activated carbon for needles to the supernatant, keep at 50-60°C, stir at 400rp / min for 35min, filter through a 0.45μm microporous membrane, remove the activated carbon for needles, filter again with a 0.22μm microporous membrane, and sterilize to obtain Sterile filtrate, the filtrate is divided into vials, and then freeze-dried.

[0082] 1. P...

specific Embodiment 2

[0085] Composition of pharmaceutical composition

[0086]

[0087]

[0088] A pharmaceutical composition of cerebroprotein hydrolyzate for injection. Take β-cyclodextrin and place it in an appropriate amount of water for injection, stir at 50°C at 500rp / min for 2h to dissolve the β-cyclodextrin, and then cool to 30°C , under stirring at 500rp / min, slowly add cerebroprotein hydrolyzate until completely dissolved, slowly add 4-aminobutyric acid under stirring at 500rp / min until completely dissolved, slowly add dextran under stirring at 500rp / min until completely dissolved, take an appropriate amount of pH Regulator (disodium hydrogen phosphate-sodium dihydrogen phosphate) to adjust the pH of the solution within the range of 7.0, stir at room temperature, centrifuge, take the supernatant, add activated carbon for needles to the supernatant, keep at 50-60 °C, and use 400rp / Stir for 35 minutes, filter through a 0.45 μm microporous membrane, remove the activated carbon for ne...

specific Embodiment 3

[0092] Composition of pharmaceutical composition

[0093]

[0094]A pharmaceutical composition of cerebroprotein hydrolyzate for injection. Take β-cyclodextrin and place it in an appropriate amount of water for injection, stir at 50°C at 500rp / min for 2h to dissolve the β-cyclodextrin, and then cool to 30°C , under stirring at 500rp / min, slowly add cerebroprotein hydrolyzate until completely dissolved, slowly add 4-aminobutyric acid under stirring at 500rp / min until completely dissolved, slowly add mannitol under stirring at 500rp / min until completely dissolved, take an appropriate amount PH adjuster (disodium hydrogen phosphate-sodium dihydrogen phosphate) to adjust the pH of the solution within the range of 7.0, stir at room temperature, centrifuge, take the supernatant, add activated carbon for needles to the supernatant, keep at 50-60 ° C, at 400rp / min and stirred for 35 minutes, filtered through a 0.45 μm microporous membrane to remove activated carbon for needles, th...

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PUM

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Abstract

The invention relates to a pharmaceutical composition of cerebrolysin vial for injection. The pharmaceutical composition comprises the main components of cerebrolysin vial and 4-aminobutyric acid.

Description

technical field [0001] The invention relates to pharmaceutical preparations, in particular to a pharmaceutical composition of cerebroprotein hydrolyzate for injection and a preparation method thereof. Background technique [0002] Nerve nutritional agents refer to a series of proteins that promote the development of the nervous system and maintain the function of the nervous system. The early neurotrophic agents are neurotrophic factors (Nerve MGrowth Factor, NMGF). The purpose of applying neurotrophic agents for neuroprotection is to intervene in the pathological and biochemical cascade reactions that occur in the penumbra, to prevent or delay cell death, and it emphasizes "early" and "protective". Neurotrophic drugs are commonly used in clinical cerebrovascular diseases It is commonly used in the treatment of cerebral ischemia, brain injury, Alzheimer's disease, Parkinson's disease, etc. [0003] Cerebroprotein hydrolyzate injection representative drugs include cerebrolys...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K38/01A61K47/26A61P3/02A61P25/00
Inventor 张隆鑫
Owner GUANGDONG LONGFU MEDICINE CO LTD
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