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Inductive osteogenesis short-chain peptide, preparation method and application thereof

A short peptide, osteogenic technology, applied in the field of clinical medicine, can solve the problems of complex preparation process, low yield, high price, etc., and achieve the effects of broad market prospects, strong osteoinductive activity, and high osteoinductive activity.

Inactive Publication Date: 2014-06-25
甘少磊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcomings of the above-mentioned prior art, especially to overcome the existing BMP-2 production equipment, preparation process is very complex, long production cycle, low yield, difficult large-scale production, too expensive and other deficiencies, To provide an osteogenic short peptide

Method used

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  • Inductive osteogenesis short-chain peptide, preparation method and application thereof
  • Inductive osteogenesis short-chain peptide, preparation method and application thereof
  • Inductive osteogenesis short-chain peptide, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] The cell test of the osteogenesis-inducing short peptide of the present invention will be introduced in detail below.

[0013]

[0014] 1. The present invention induces the synthesis of osteogenic short peptide

[0015] The osteogenesis-inducing short peptide KIPKASSVPTE LSAISTL of the present invention is obtained by the FMOC / tBu solid-phase peptide synthesis method known in the art.

[0016]

[0017] 2. Cell Assay

[0018] (1) Test-related instruments and equipment

[0019] equipment name model Manufacturer clean bench NU-126-006 Nuaire Research Grade Inverted Microscope IX41 OLYMPUS Refrigerated centrifuge 5810R EPPENDORF carbon dioxide incubator NU4750E Nuaire

[0020] (2) Test-related materials

[0021] One SD MSC strain (RASMX-01001), source: Cyagen

[0022] Cell status: The cell status is good and the shape is uniform.

[0023] Cell sterility test result: negative

[0024] (3) Test-related reagents

[0...

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PUM

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Abstract

The invention relates to an inductive osteogenesis short-chain peptide. A structure formula of the inductive osteogenesis short-chain peptide is shown as KIPKASSVPTELSAISTL. The inductive osteogenesis short-chain peptide has strong osteogenesis inducing activity and can be synthesized in a large scale at low cost. The invention overcomes the defect that current BMP-2 (Bone Morphogenetic Protein-2) production devices and preparation processes are very complicated, have long production cycle, low productivity, a small possibility of producing in large scale and excessively high cost; the inductive osteogenesis short-chain peptide is wide in market prospect.

Description

technical field [0001] The invention belongs to the field of clinical medicine, and more specifically relates to an osteogenesis-inducing short peptide, its preparation method and its application in the preparation of medicines for promoting bone regeneration and bone defect repair. Background technique [0002] Chinese society is gradually entering an aging society, and the incidence of middle-aged and elderly orthopedic diseases will also increase significantly. Therefore, China will also face a huge demand for artificial bone graft materials. According to statistics, there are 15 million patients with limb insecurity in China, and 3 million people have amputated their limbs due to lack of reconstruction technology and materials. There are nearly 3.5 million patients with bone defects and bone injuries in the country every year. Calculated on the basis of 400,000 operations per year, the entire Chinese bone graft material The market size of China will also reach a scale of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/08C07K1/16C07K1/04A61K38/10A61P19/08
Inventor 甘少磊
Owner 甘少磊
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