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Induced osteogenesis polypeptide, and preparation method and purposes thereof

An osteogenic polypeptide and application technology, applied in the field of clinical medicine, can solve the problems of complex preparation process, low yield and high price, and achieve the effects of strong osteoinductive activity, broad market prospect and high osteoinductive activity

Inactive Publication Date: 2014-03-26
北京博恩康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcomings of the above-mentioned prior art, especially to overcome the existing BMP-2 production equipment, preparation process is very complex, long production cycle, low yield, difficult large-scale production, too expensive and other deficiencies, To provide an osteogenic polypeptide

Method used

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  • Induced osteogenesis polypeptide, and preparation method and purposes thereof
  • Induced osteogenesis polypeptide, and preparation method and purposes thereof
  • Induced osteogenesis polypeptide, and preparation method and purposes thereof

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] The cell test of the osteogenesis-inducing polypeptide of the present invention will be described in detail below.

[0012]

[0013] 1. The present invention induces the synthesis of osteogenic polypeptide

[0014] The osteogenesis-inducing polypeptide KIPKASSVPTE LSAISTLYLCC of the present invention is obtained by the FMOC / tBu solid-phase polypeptide synthesis method known in the art.

[0015]

[0016] 2. Cell Assay

[0017] equipment name model Manufacturer clean bench NU-126-006 Nuaire Research Grade Inverted Microscope IX41 OLYMPUS Refrigerated centrifuge 5810R EPPENDORF carbon dioxide incubator NU4750E Nuaire

[0018] (2) Test-related materials

[0019] One SD MSC strain (RASMX-01001), source: Cyagen

[0020] Cell status: The cell status is good and the shape is uniform.

[0021] Cell sterility test result: negative

[0022] (3) Test-related reagents

[0023] SD Rat Mesenchymal Stem Cell Complete Medium (R...

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Abstract

The invention relates to an induced osteogenesis polypeptide which has the structural formula of KIPKASSVPTELSAISTLYLCC. The induced osteogenesis polypeptide has the advantages of stronger osteoinductive activity, large-scale synthesis and lower price, overcomes the deficiencies of complexity in preparation technology, long production period, low yield, difficulty in large-scale production, high price, and the like in the conventional genetic recombination BMP-2 production equipment and the preparation process, and has wide market prospects.

Description

technical field [0001] The invention belongs to the field of clinical medicine, and more specifically relates to an osteogenesis-inducing polypeptide, its preparation method and its application in the preparation of medicines for promoting bone regeneration and bone defect repair. Background technique [0002] Chinese society is gradually entering an aging society, and the incidence of middle-aged and elderly orthopedic diseases will also increase significantly. Therefore, China will also face a huge demand for artificial bone graft materials. According to statistics, there are 15 million patients with limb insecurity in China, and 3 million people have amputated their limbs due to lack of reconstruction technology and materials. There are nearly 3.5 million patients with bone defects and bone injuries in the country every year. Calculated on the basis of 400,000 operations per year, the entire Chinese bone graft material The market size of China will also reach a scale of m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/51A61K38/18A61P19/00
CPCC07K14/51A61K38/00
Inventor 甘少磊王超
Owner 北京博恩康生物科技有限公司
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