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Induced osteogenesis oligopeptide and preparation method and applications thereof

A short peptide and osteogenic technology, which is applied in the field of clinical medicine, can solve the problems of complex preparation process, low yield, and high price, and achieve the effect of strong osteoinductive activity, broad market prospect, and high osteoinductive activity

Inactive Publication Date: 2014-03-26
北京博恩康生物科技有限公司
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Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcomings of the above-mentioned prior art, especially to overcome the existing BMP-2 production equipment, preparation process is very complex, long production cycle, low yield, difficult large-scale production, too expensive and other deficiencies, To provide an osteogenic short peptide

Method used

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  • Induced osteogenesis oligopeptide and preparation method and applications thereof
  • Induced osteogenesis oligopeptide and preparation method and applications thereof

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Embodiment Construction

[0014] The ectopic osteogenesis test in animals of the osteogenesis-inducing short peptide of the present invention will be introduced in detail below, and the test results will be illustrated in conjunction with the corresponding drawings.

[0015]

[0016] 1. The present invention induces the synthesis of osteogenic short peptide

[0017] The osteogenesis-inducing short peptide GGCCSKIPKASSVPTE LSAISTLYLDY of the present invention is obtained by the FMOC / tBu solid-phase peptide synthesis method known in the art.

[0018] 2. In vivo ectopic osteogenesis experiments in animals

[0019] I. Test process

[0020] The "Ruifu" absorbable artificial bone material (provided by Beijing Yierkang Bioengineering Development Center) was cut into discs with a diameter of 7mm and a thickness of about 1.5mm, and sterilized with Co60 irradiation (2.5Mrad). Dissolve the osteogenic short peptide of the present invention with double distilled water under sterile conditions, soak the sterilize...

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Abstract

The invention relates to an induced osteogenesis oligopeptide with the structure formula of GGCCSKIPKASSVPTELSAISTLYLDY. The induced osteogenesis oligopeptide has the advantages of being strong in osteoinductive activity, capable of being synthesized on large scale, and low in price, can be used for overcoming the deficiencies that the existing BMP-2 production equipment and preparation technology are complicated, long in production period, low in yield, difficult to produce on large scale, expensive in price and the like, thus being wide in market prospects.

Description

technical field [0001] The invention belongs to the field of clinical medicine, and more specifically relates to an osteogenesis-inducing short peptide, its preparation method and its application in the preparation of medicines for promoting bone regeneration and bone defect repair. Background technique [0002] Chinese society is gradually entering an aging society, and the incidence of middle-aged and elderly orthopedic diseases will also increase significantly. Therefore, China will also face a huge demand for artificial bone graft materials. According to statistics, there are 15 million patients with limb insecurity in China, and 3 million people have amputated their limbs due to lack of reconstruction technology and materials. There are nearly 3.5 million patients with bone defects and bone injuries in the country every year. Calculated on the basis of 400,000 operations per year, the entire Chinese bone graft material The market size of China will also reach a scale of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/51A61K38/18A61P19/00
CPCC07K14/51A61K38/00
Inventor 甘少磊任卫卫王超
Owner 北京博恩康生物科技有限公司
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