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Drug composition for treating oral mucosa lichen planus

A technology for lichen planus and oral mucosa, applied in the field of medicine, can solve problems such as unsatisfactory curative effect, achieve satisfactory curative effect, accelerate healing, and promote cell proliferation

Inactive Publication Date: 2014-06-25
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term external use of glucocorticoids often produces adverse reactions such as local atrophy, infection, and telangiectasia. The curative effects of antibiotic solution gargle and 0.1% retinoic acid ointment are not satisfactory.
[0003] All in all, there is currently no very effective drug for the treatment of oral lichen planus in clinical practice. Therefore, finding effective intervention drugs has very important theoretical significance and application value

Method used

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  • Drug composition for treating oral mucosa lichen planus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Dry 1.2kg of glutinous rice roots and 0.2kg of peanut shells, add 20L of 80% ethanol, heat and reflux for extraction for 2 hours, filter, discard the filtrate, add 15L of 80% ethanol to the filter residue, heat and reflux for 1.5h, filter, discard the filtrate, filter residue Add 20L of pure water to it, heat and reflux to extract twice respectively, combine the filtrates, concentrate to a paste, freeze-dry and vacuumize to obtain a freeze-dried powder.

Embodiment 2

[0017] Dry 1.2kg of glutinous rice roots and 0.4kg of peanut shells, add 22L of 85% ethanol, heat and reflux for extraction for 2 hours, filter, discard the filtrate, add 16L of 85% ethanol to the filter residue, heat and reflux for 1.5h, filter, discard the filtrate, filter residue Add 20L of pure water to it, heat and reflux to extract twice respectively, combine the filtrates, concentrate to a paste, freeze-dry and vacuumize to obtain a freeze-dried powder.

Embodiment 3

[0019] Dry 1.2kg of glutinous rice root and 0.24kg of peanut shell, add 20L of 80% ethanol, heat and reflux for extraction for 2 hours, filter, discard the filtrate, add 15L of 80% ethanol to the filter residue, heat and reflux for 1.5h, filter, discard the filtrate, filter residue Add 20L of pure water to it, heat and reflux to extract twice respectively, combine the filtrates, concentrate to a paste, freeze-dry and vacuumize to obtain a freeze-dried powder.

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Abstract

The invention discloses a drug composition for treating oral mucosa lichen planus. The composition comprises an active ingredient and pharmaceutical adjuvants, wherein the active ingredient is obtained by mixing glutinous rice roots and peanut shells and then extracting the mixture with water. Acting on buccal mucosa fibroblasts, the drug composition can promote proliferation of the fibroblasts, thus greatly improving the lesion region repair capacities of the fibroblasts and accelerating lesion healing.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular relates to a traditional Chinese medicine extract, in particular to a pharmaceutical composition for treating oral mucosal lichen planus. Background technique [0002] Oral lichenplanus (OLP) is an inflammatory skin and mucosal disease mediated by T cells of unknown etiology, and is one of the common diseases of oral mucosa. Modern medicine also has no clear etiology of oral lichen planus. It is believed that it may be related to mental factors, infections, drugs, chronic lesions, systemic diseases, enzyme abnormalities, endocrine abnormalities, or qi stagnation and blood stasis. This disease is prone to occur in middle-aged people, and women are more than men. Current local treatments include gargling with antibiotic solution, intralesional injection or topical corticosteroids, and 0.1% tretinoin ointment. However, long-term topical glucocorticoids often produce adverse reaction...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P1/02
Inventor 赵晓梅张勇哲国娥香王多诚蔡洁凤
Owner QINGDAO MUNICIPAL HOSPITAL
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