Salts of (-)sukhodianine derivative

A technology for compounds and drugs, applied in the field of medicinal chemistry, can solve problems such as adverse reactions and unsatisfactory drug treatment effects, and achieve the effect of practical therapeutic activity

Inactive Publication Date: 2014-06-18
SHANGHAI YIZHI MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] For now, although there are many kinds of drugs against methicillin-resistant Staphylococcus aureus, the existing drugs are likely to cause multiple and severe adverse reactions, and the therapeutic effect of the existing drugs is still not ideal.

Method used

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  • Salts of (-)sukhodianine derivative
  • Salts of (-)sukhodianine derivative
  • Salts of (-)sukhodianine derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Suhedinine fumarate

[0048] Dissolve 3.55 g (0.01 mol) of the compound styrenine and 1.17 g (0.01 mol) of fumaric acid in 95 ml of boiling ethanol. The hot solution was filtered through diatomaceous earth, then slowly cooled under gentle stirring, and stood for several hours at a temperature of 0-5°C to precipitate styrodin fumarate crystals, and styrodin fumarate was filtered out. Salt crystals were washed with ethanol and dried under vacuum at 50°C to obtain 4.70 g of product.

Embodiment 2

[0050] Suhedinine fumarate

[0051] Stir 3.55 g of the compound styrodinine fumarate and 1.17 g of fumaric acid in 95 ml of refluxing ethanol until all the solids are dissolved. Add activated carbon, filter the hot solution through diatomaceous earth, and cool down to room temperature while stirring. After standing for several hours in a temperature environment of 0-5°C, the crystals of styrodinine fumarate are precipitated, the crystals of styrodinine fumarate are filtered out, washed with ethanol and dried under vacuum at 50°C to obtain 4.69 g of product.

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Abstract

The invention relates to (-)sukhodianine, a fumarate of a (-)sukhodianine derivative, or a pharmacologically acceptable solvate of the fumarate, and applications of the pharmacologically acceptable solvate in preparation of drugs used for controlling methicillin-resistant staphylococcus aureus.

Description

field of invention [0001] The present invention relates to the field of medicinal chemistry, in particular, the present invention relates to (-)-sukhodianine organic acid salt and its pharmaceutical application. Background technique [0002] For now, although there are many kinds of drugs against methicillin-resistant Staphylococcus aureus, these existing drugs are likely to cause multiple and severe adverse reactions, and the therapeutic effect of the existing drugs is still not ideal. The patent specification of Chinese invention patent application publication number CN 101822675A describes some active compounds against methicillin-resistant Staphylococcus aureus. Contents of the invention [0003] The present invention discloses some new compounds, preparation methods of these compounds, pharmaceutical compositions containing these compounds and pharmaceutical applications of these compounds and compositions. [0004] These compounds exhibit good water solubility stabi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D491/06C07C57/15C07C51/41A61K31/4355A61P31/04
CPCC07D491/06
Inventor 不公告发明人
Owner SHANGHAI YIZHI MEDICAL TECH
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