Cavity ring down spectroscopy (CRDS) technique based blood component recognizing and analyzing instrument

Abstract

The invention discloses a cavity ring down spectroscopy (CRDS) technique based blood component recognizing and analyzing instrument. The instrument comprises an optical platform, a blood volatile gas collecting device, an analog-digital converter and a computer, wherein the optical platform comprises a laser light source module, an optical oscillating cavity, a thin film pressure sensor and a photomultiplier. According to the instrument disclosed by the invention, the concentration of volatile organic compounds (VOCs) in blood volatile gas is detected by utilizing low-cost ultra-sensitivity and high-accuracy CRDS technique and a background deduction method, so that different blood components can be detected.

Description

technical field [0001] The invention relates to the technical field of blood component detection, in particular to a blood component identification and analysis instrument based on optical cavity ring-down spectroscopy technology. Background technique [0002] Blood component detection technology has been a research hotspot in the field of biomedical sensing in recent years. Blood components reflect various indicators of the body's physiology, including blood sugar, blood lipids, cholesterol levels, and the content of various enzymes and proteins. In addition to such biological macromolecules, plasma contains very complex small molecular components, including monosaccharides , fatty acids, ketone bodies and various volatile organic compounds (volatile organic compounds, VOCs), such as ammonia (NH 3 ), ethanol (CH 3 CH 2 OH), acetone [(CH 3 ) 2 CO] etc. These small molecular organic substances are closely related to the physiological state of the body, and the abnormali...

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Problems solved by technology

[0004] 1. The blood component analysis method uses a blood biochemical analyzer, which takes a long time and is complicated to detect. Various biochemical treatments need to be performed on the blood sample, which is prone to result deviations

The detection indicators are limited to a limited number of important enzymes and some lipoproteins and other macromolecules; and it cannot detect small molecular substances such as important intermediates or end products of body metabolism

Therefore, in terms of metabolic monitoring and blood component identification, traditional blood biochemical analysis will lose a large part of the blood component information about metabolic small molecules

[0005] 2. The chemical reaction test paper detection method has a fast detection speed, but it can only detect a single component, and the test paper method consumes a lot of disposable test paper, so the cost is very high

However, the specificity of this method is not strong, and frequent calibration is required, and the measurement error is large

In addition, sample residue will also affect the service life of the sensor

[0007] 4. Transmission or scattering spectroscopy, which can obtain rich optical information of blood components, but its detection accuracy is not high, and the positioning of blood components of various small molecules is not accurate

Therefore, there are currently no products that can actually be used in clinical trials

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