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Application of senkyunolide I in treating diseases

A chuanxiong lactone, a technology for treating diseases, applied in the field of chuanxiong to absorb ingredients, can solve the problems that antidepressants cannot promote gastrointestinal motility, low satisfaction with curative effect, and cannot improve depression.

Inactive Publication Date: 2014-06-04
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this condition, the current treatment dilemma stems from (1) antidepressants cannot promote gastrointestinal motility, and even have side effects of depressed gastrointestinal motility
(2) Drugs that promote gastrointestinal motility cannot improve depression
[0004] In the face of dyspepsia in depression, there is no suitable drug for the current treatment plan. Antidepressants can only be used in combination with some gastrointestinal motility drugs such as domperidone. The disadvantages
[0005] (1) Selective 5-HT reuptake inhibitor (SSRI), the first-line antidepressant, not only cannot help gastrointestinal motility, but has side effects of inhibiting gastrointestinal motility and is forced to stop the drug
[0006] (2) The onset time of antidepressant drugs generally takes more than 4 weeks, and patients need to endure the long-term toxic and side effects of chemically synthesized drugs, and the satisfaction with the curative effect is low
[0007] (3) The use of multiple chemicals to cope with depression and functional dyspepsia, causing a huge burden on patients

Method used

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  • Application of senkyunolide I in treating diseases

Examples

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Comparison scheme
Effect test

Embodiment 1

[0022] A research method for treating indigestion and depression effect of Chuanxiong Rhizoma Chuanxiong, the research method for treating indigestion comprises the following steps:

[0023] ① Rats were intraperitoneally injected with cisplatin 15mg / kg, and after 2 hours, each group was given drugs respectively, and after 30 minutes of intragastric administration, each rat was intragastrically administered with 1ml Evansblue;

[0024] ②. After 30 minutes, the rats were sacrificed by neck dislocation, laparotomy, gastric cardia and pylorus were ligated, the stomach was taken out, and the small intestine was pulled out to measure the propulsion ratio of the small intestine. A large amount of Evansblue remained in the stomach, some remained on the gastric wall mucosa, and a small part was left after 30 minutes. can be absorbed by the gastric mucosa,

[0025] ③Put the stomach and its contents in 15ml of 0.1N NaOH, and then homogenize it. Dilute the homogenized specimen with 0.1N N...

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Abstract

The invention provides an application of an absorption component of ligusticum wallichii senkyunolide I in treating functional dyspepsia, depression and depression-based dyspepsia. The senkyunolide I is characterized by effectively treating functional dyspepsia, depression and depression-based dyspepsia.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to the use of chuanxionglide I, an absorption component of Chuanxiong, in the treatment of functional dyspepsia, depression and dyspepsia based on depression. Background technique [0002] Depression and functional dyspepsia have a very high comorbidity rate, and patients with depression are often accompanied by symptoms such as loss of appetite and gastrointestinal motility. For this condition, the current treatment dilemma stems from (1) antidepressant drugs cannot promote gastrointestinal motility, and even have side effects of depressive gastrointestinal motility. (2) Drugs that promote gastrointestinal motility cannot improve depression. How to simultaneously regulate the brain-gut synchronization disorder caused by stress and stress is a major technical problem. [0003] However, the traditional theory of traditional Chinese medicine "stagnation of liver qi" incl...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P1/14A61P25/24A61D7/00
Inventor 黄熙骆敏黄云柯任平
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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