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Method for treating cancer by combined application of c-MET inhibitor and sodium butyrate

A combined application and inhibitor technology, applied in gene therapy, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of cancer that cannot be eradicated, and achieve the effects of easy use and promotion, reduction of recurrence rate, and growth inhibition

Inactive Publication Date: 2014-05-21
JIANGSU LIFECEL TECH
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, studies have also shown that when sodium butyrate is used to treat cancers such as colon cancer and breast cancer, cancer often cannot be eradicated and cancer recurrence occurs

Method used

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  • Method for treating cancer by combined application of c-MET inhibitor and sodium butyrate
  • Method for treating cancer by combined application of c-MET inhibitor and sodium butyrate
  • Method for treating cancer by combined application of c-MET inhibitor and sodium butyrate

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Embodiment Construction

[0018] A method for the combined application of c-MET inhibitors and sodium butyrate to treat cancer, the method is to administer sodium butyrate preparations and c-MET inhibitors to cancer patients simultaneously, and the cancers include breast cancer, colon cancer and Liver cancer, the sodium butyrate preparation is an oral preparation, injection or sustained-release preparation, the c-MET inhibitor is a substance that inhibits or reduces the transcription of the c-MET gene, and the c-MET inhibitor is a substance that inhibits or reduces c- The substance translated by the MET gene, the c-MET inhibitor is a substance that can antagonize the normal biological function of the c-MET protein, and the administration methods of the sodium butyrate preparation and the c-MET inhibitor include intravenous injection, oral administration and topical administration , the sodium butyrate preparation and the c-MET inhibitor can be administered separately.

[0019] like figure 1 As shown, ...

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Abstract

The invention relates to the technical field of cancer treatment methods, and in particular relates to a method for treating cancer by the combined application of a c-MET inhibitor and sodium butyrate. The method comprises the step of administrating a drug to a cancer patient through a sodium butyrate preparation and the c-MET inhibitor simultaneously. According to the method for treating the cancer by the combined application of the c-MET inhibitor and sodium butyrate, the growth of a tumor can be effectively inhibited, and the number of tumor stem cells is effectively decreased; moreover, the transplantation efficiency of cancer cells is effectively inhibited, the recurrence rate of the cancer is greatly reduced, and the method is easy to use and popularize.

Description

technical field [0001] The invention relates to the technical field of a cancer treatment method, in particular to a method for treating cancer with a combination of c-MET inhibitor and sodium butyrate. Background technique [0002] Sodium butyrate is a metabolite of coliform bacteria. It can regulate the expression of many genes in cells by inhibiting the action of histone deacetylation kinase. For example, sodium butyrate can induce cell growth cycle arrest, apoptosis or differentiation. Based on the above principles, many studies have also shown that sodium butyrate has a therapeutic effect on a variety of cancers. For example, sodium butyrate can induce apoptosis of breast cancer cells by inducing caspase-10. So sodium butyrate is also considered as a candidate chemical drug for the treatment of cancer. However, studies have also shown that when sodium butyrate is used to treat cancers such as colon cancer and breast cancer, cancer often cannot be eradicated and canc...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K48/00A61P35/00A61K31/19
Inventor 孙博
Owner JIANGSU LIFECEL TECH
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