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Use of infant formula with cholesterol

A cholesterol and purpose technology, applied in the directions of medical preparations, pharmaceutical formulations, and applications containing active ingredients, can solve the problem of not raising the effect of blood cholesterol

Inactive Publication Date: 2014-05-14
NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, these literatures do not address the role of the location of dietary cholesterol early in life in terms of blood cholesterol-reducing effects later in life

Method used

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  • Use of infant formula with cholesterol
  • Use of infant formula with cholesterol
  • Use of infant formula with cholesterol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] Example 1: Programming effects of lipid globule structure on plasma cholesterol levels later in life

[0104] The infant formula was prepared similarly to Example 1B of WO2010 / 0027258.

[0105] 1) Control IMF: The diet contained 255 g lipid per kg dry weight. Lipid globules are small. No polar lipids added. Lipids comprise about 47% of total calories digestible carbohydrates, about 45 and about 8% of total calories protein.

[0106] 2) IMF with added phospholipids and cholesterol: This diet differs from Diet 1 in that it contains small lipid globules and dry blend added phospholipids (PL) and cholesterol from milk, i.e. the phospholipids are not located in the The outer surface layer of lipids.

[0107] 3) IMF of the invention: This diet differs from diet 1 in that the small lipid globules comprise a coating containing phospholipids and cholesterol derived from milk

[0108] 4) IFM according to the invention: This diet differs from diet 3 in that it contains larg...

Embodiment 2

[0120] Example 2: Programming effects of lipid globule structure on plasma cholesterol levels later in life

[0121] The experiment of Example 1 was repeated with a diet similar to Diets 1 and 4 of Example 1. Male Wistar rats were used instead of mice. Blood was analyzed on day 42 (direct dietary effects) and day 130 (later in life, programming effects), but not day 98. The amount of phospholipids in meal 4 was 1.6% by weight based on total fat (0.11% by weight in meal 1). The amount of cholesterol in Meal 4 was 0.03% by weight based on total fat. Linoleic acid and α-linolenic acid (α-linoleinic acid) in meals 1 and 4 were the same as those in Example 1. The volume mode diameter of the lipid globules of meal 1 was 0.5 μm. The diameter below 10% by volume is 2-12 μm. The volume mode diameter of the lipid globules of meal 4 was 1.7 μm. More than 45% by volume is 2-12 μm in diameter.

[0122] Table 2: Total blood cholesterol levels and triglyceride (TG) levels (mmol / l) o...

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Abstract

The invention relates to an infant nourishment comprising lipid globules with a coating of phospholipids comprising dietary cholesterol. The infant nourishment has programming effects on the body and results in a reduced level of total blood cholesterol later in life when consuming a western style diet, and therefore the risk on western life style diseases as atherosclerosis and other vascular diseases later in life can be reduced.

Description

technical field [0001] The invention belongs to the field of infant nutritional products, in particular to the field of health effects of early-life nutritional products in later life. Background technique [0002] Breastfeeding is the preferred method of feeding babies. But there are situations where breastfeeding is not possible or so desirable. In these cases, infant formula is a good alternative. The composition of modern infant formula is adapted to the many specific nutritional needs of rapidly growing and developing infants. It also appears that some improvements can be made in the composition of infant formula. [0003] Human milk typically has a cholesterol content of 0.34-1.3% by weight based on total lipids (Jensen, 1999, Lipids 34, 1243-1271). On the other hand, standard infant formula does not contain cholesterol. Thus, breastfed infants have higher blood cholesterol levels than bottle fed infants as long as breastfeeding has been present (Kallio et al, 199...

Claims

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Application Information

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IPC IPC(8): A23L1/29A23L1/30A61K31/20A61K31/201A23L33/00
CPCA23L33/12A23L33/30A23L33/115A23L33/40A61K31/201A61K31/232A61K2300/00
Inventor M·阿布拉哈姆瑟-伯克维尔德E·M·范德比克H·J·M·范德海吉恩
Owner NUTRICIA
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