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Ginsenoside-containing vegetable oil adjuvant and preparation method and application thereof

A technology of ginsenoside and vegetable oil, which is applied in the field of ginsenoside-containing vegetable oil adjuvants and its preparation, can solve problems such as residues, and achieve the effects of improved safety, low viscosity, and convenient immune injection

Inactive Publication Date: 2014-04-30
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented new type of oil called triglycerol ester (TGE), made from natural plant sources like castor bean or rosemary seed, was developed because it could improve the efficacy of certain drugs when given alone without causing side effects such as inflammations that may affect healthy individuals' blood vessels. It also enhances the ability of these substance to help protect against diseases caused by bacteria. Overall, this technology allows safe use of pharmaceuticals during veterinary medicine procedures.

Problems solved by technology

This patented technical problem addressed in this patents relates to developing novel veterinary medications called OVA (oily cold syndrome) vaccums without harmful substances like phosphorus acid ester compounds found in conventional methods involving complex processes. Existing chemical agents often require multiple steps and may result in contamination issues due to their negative impact upon human health. There is therefore a demand for improved alternatives made from natural products instead of chemically synthged ones.

Method used

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  • Ginsenoside-containing vegetable oil adjuvant and preparation method and application thereof
  • Ginsenoside-containing vegetable oil adjuvant and preparation method and application thereof
  • Ginsenoside-containing vegetable oil adjuvant and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Example 1 Preparation of sunflower oil adjuvant containing ginsenosides

[0038] (1) Weigh 0.50 g of ginseng stem and leaf saponins (products of Jilin Hongjiu Pharmaceutical Co., Ltd.), add it to 10 mL of dimethyl sulfoxide (DMSO), mix well, and dissolve to make a solution containing 50 mg of ginseng stem and leaf saponins per ml. spare.

[0039] (2) Add 1 mL of the above-mentioned ginseng saponins solution to 1000 mL of sunflower oil (product of Shanghai Kerry Food Industry Co., Ltd.), and mix thoroughly to obtain a vegetable oil adjuvant containing 43 μg of ginseng saponins per mL.

Embodiment 2

[0040] Example 2 Preparation of corn oil adjuvant containing ginsenosides

[0041] (1) Weigh 0.50 g of ginseng stem and leaf saponins (products of Jilin Hongjiu Pharmaceutical Co., Ltd.), add it to 10 mL of dimethyl sulfoxide (DMSO), mix well, and dissolve to make a solution containing 50 mg of ginseng stem and leaf saponins per ml. spare.

[0042] (2) Add 1mL of the above-mentioned ginseng saponins solution to 1000mL corn oil (product of Shanghai Kerry Food Industry Co., Ltd.), and mix thoroughly to obtain a vegetable oil adjuvant containing 43 μg of ginseng saponins per ml.

Embodiment 3

[0043] Example 3 Preparation of olive oil adjuvant containing ginsenosides

[0044] (1) Weigh 0.50 g of ginseng stem and leaf saponins (products of Jilin Hongjiu Pharmaceutical Co., Ltd.), add it to 10 mL of dimethyl sulfoxide (DMSO), mix well, and dissolve to make a solution containing 50 mg of ginseng stem and leaf saponins per ml. spare.

[0045] (2) Add 1mL of the above-mentioned ginseng stem and leaf saponin solution to 1000mL olive oil (product of Shanghai Kerry Food Industry Co., Ltd.), and mix well to obtain a vegetable oil adjuvant containing 3 μg of ginseng stem and leaf saponin per ml.

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Abstract

The invention discloses a ginsenoside-containing vegetable oil adjuvant and a preparation method and application thereof. The ginsenoside-containing vegetable oil adjuvant is characterized in that edible vegetable oil is used as the adjuvant oil; the ginsenoside-containing vegetable oil adjuvant comprises 10 to 100mu g/mL ginsenoside. According to the preparation method, the ginsenoside-containing vegetable oil is utilized for preparing vaccines, so that the vaccine safety can be greatly improved, and the potential hazard of the general mineral oil adjuvant on food hygiene is avoided; after being mixed, ginsenoside and vegetable oil play the effect of collaborating with the adjuvant, thus the valence of antibody is raised by 4.7 times, and the antibody level of the vaccines is also greatly improved; in addition, the prepared vaccine is high in mobility, convenient for inoculation, small in local stimulation, and thus relieving pain on animals; when the ginsenoside-containing vegetable oil adjuvant is applied to vaccine production, the existing production process is remained, and the method is simple and convenient.

Description

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Claims

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Application Information

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Owner ZHEJIANG UNIV
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