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Preparation method of traditional Chinese medicinal oral liquid for treating tourette syndrome of children

A technology for oral liquid and multiple tics, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc., and can solve the problems of unstable safety and poor clarity of oral liquids.

Inactive Publication Date: 2014-04-30
南京海思创新生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The object of the present invention is to provide a kind of preparation method of the oral liquid of traditional Chinese medicine for the treatment of infantile tic syndrome, solve the poor clarity of the oral liquid existing in the original preparation process, instability and safety problems, optimize each parameter in the process, improve the preparation as far as possible Quality, easy for quality control, and improve the mouthfeel of the oral liquid, improve children's compliance

Method used

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  • Preparation method of traditional Chinese medicinal oral liquid for treating tourette syndrome of children
  • Preparation method of traditional Chinese medicinal oral liquid for treating tourette syndrome of children
  • Preparation method of traditional Chinese medicinal oral liquid for treating tourette syndrome of children

Examples

Experimental program
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Effect test

Embodiment 1

[0124] Embodiment 1, a kind of preparation method of oral liquid for the treatment of infantile tic, the steps are as follows:

[0125] (1). Take white peony root, silkworm, gastrodia elata, uncaria, turmeric, earthworm and scorpion, add 50% ethanol to the extraction tank, reflux and extract at 80-90°C for 2 hours, then take out the extract, Carry out the second and third extractions according to the method of the first extraction, combine the three extracts, filter, and recover ethanol from the filtrate under reduced pressure, (paeoniflorin is unstable) and concentrate under reduced pressure to a relative density of 1.05-1.1 (60°C ); add distilled water, stir while adding, let stand and refrigerate for 24-48 hours, filter, and obtain;

[0126] (2). Take the raw ground, combine with the dregs obtained in step (1), put it into the extraction tank, and add water to the extraction tank, then heat and decoct the extraction tank for the first time for 1 hour, and take out the decoc...

Embodiment 2

[0129] Embodiment 2, a kind of preparation method of oral liquid for the treatment of infantile tic, the steps are as follows:

[0130] (1). Take white peony root, silkworm, gastrodia elata, uncaria, turmeric, earthworm and scorpion, add 50% ethanol whose quality is 6 times the quality of traditional Chinese medicine to the extraction tank, and reflux extraction at 90°C for 2 hours Finally, take out the extract, carry out the second and third extractions according to the method for the first extraction, combine the three extracts, filter through a 100-120 mesh filter, and recover ethanol from the filtrate under reduced pressure, (paeoniflorin is unstable) Concentrate under pressure until the relative density is 1.05-1.1 (60°C); add 6 times of distilled water, stir while adding, let it stand for 24 hours in refrigeration, filter through a 100-120 mesh filter, and get the product;

[0131] (2). Take the raw ground, combine with the medicinal residue obtained in (1), put it into ...

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Abstract

A preparation method of traditional Chinese medicinal oral liquid for treating tourette syndrome of children includes performing reflux extraction on radix paeoniae alba, bombyx batryticatus, gastrodia elata, uncaria rhynchophylla, radix curcumae, pheretima and buthus martensii, filtering, recovering ethanol, concentrating, adding distilled water, standing, and refrigerating; mixing rehmannia glutinosa libosch and the medicinal residue, decocting in water, filtering, concentrating, adding ethanol, standing, collecting supernatant, and filtering to obtain water extraction / ethanol precipitation liquid; mixing water extraction / ethanol precipitation liquid and ethanol extraction / water precipitation liquid, recovering ethanol, heating, concentrating, standing, filtering to obtain filtrate; mixing 1 / 3 volume of the filtrate with steviosin, stirring, mixing with the rest 2 / 3 of the filtrate, adding ethylparaben, adding water, regulating pH value, and standing; and centrifuging, collecting supernatant, adding water to regulate total volume to 1,000 mL, stirring, subpackaging, and sterilizing. Through improvement on the basis of the original process, the preparation method provided by the invention improves preparation appearance, solves the problems of poor clarity and stability in the original process, and ensures safety and efficacy of medicament in children.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine oral liquid for treating infantile tics. Background technique [0002] Tourette's syndrome is a chronic neuropsychiatric disorder with onset in childhood, usually accompanied by abnormal movement and behavior. Its clinical manifestations are mainly sudden, rapid, repetitive, non-rhythmic, involuntary and stereotyped motor tics and vocal tics in children, as well as some accompanying psychological and behavioral disorders. Most children have one or more groups of muscle unconscious repetitions. Tics and various vocal disturbances (such as strange calls, repetitive language or imitation of language, etc.), and have a chronic course, come and go slowly, easy to fluctuate and recurrent. If the disease is not treated in an early, timely, reasonable and effective manner, the mental development, cognitive ability and social adaptability of some children may be affected to varying...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/00A61P25/14A61K35/56A61K35/64A61K35/62A61K35/646
Inventor 储益平管伦兴朱华荣
Owner 南京海思创新生物科技有限公司
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