Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method and application of up-converted nano particle and graphene oxide composite material

A technology of nanoparticles and composite materials, which is applied in the field of preparation of fluorescent probe nanomaterials to achieve good water solubility

Inactive Publication Date: 2014-04-02
TIANJIN NORMAL UNIVERSITY
View PDF2 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to intralamellar sp 3 district and sp 2 The random distribution of regions, GO exhibits peculiar electrical and optical properties, and is considered to be a functionalized graphene material, which has important theoretical research and application value. At present, all research on graphene composite materials is in its infancy. Opportunities and challenges coexist

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application of up-converted nano particle and graphene oxide composite material
  • Preparation method and application of up-converted nano particle and graphene oxide composite material
  • Preparation method and application of up-converted nano particle and graphene oxide composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] 1) Preparation of water-soluble folic acid-functionalized upconversion particles:

[0052] a) Preparation of rare earth nitrates: 0.4 mmol yttrium oxide Y 2 o 3 , 0.09mmol ytterbium oxide Yb 2 o 3 , 0.01mmol erbium oxide Er 2 o 3 , that is, the ratio of the amount of yttrium, ytterbium, and erbium Y / Yb / Er = 80 / 18 / 2, Y+Yb+Er=1mmol, weigh the mass, put it into a 50mL small beaker, add 1.5mL concentrated nitric acid, 4mL High-purity water, nitrated at 100oC in a fume hood, evaporated to dryness; among them, Yttrium oxide Y 2 o 3 The amount of Y in the substance is 0.8mmol, ytterbium oxide Yb 2 o 3 The amount of substance in Yb is 0.18mmol, erbium oxide Er 2 o 3 The amount of substance in Er is 0.02mmol;

[0053] b) Preparation of diethylene glycol-modified upconversion particles: Weigh 4mmol NaF, put it in a 100mL round bottom flask, add 2mL diethylene glycol + 8mL high-purity water, and heat it to 160oC with an oil bath under nitrogen protection and magneti...

Embodiment 2

[0062] 1) Preparation of water-soluble folic acid-functionalized upconversion particles:

[0063] a) Preparation of rare earth nitrates: 0.4 mmol yttrium oxide Y 2 o 3 , 0.09mmol ytterbium oxide Yb 2 o 3 , 0.01mmol erbium oxide Er 2 o 3 , that is, the ratio of the amount of yttrium, ytterbium, and erbium Y / Yb / Er = 80 / 18 / 2, Y+Yb+Er=1mmol, weigh the mass, put it into a 50mL small beaker, add 3mL concentrated nitric acid, 4mL high-purity water , in a fume hood at 100oC, nitrify and evaporate to dryness; where Yttria Y 2 o 3 The amount of Y in the substance is 0.8mmol, ytterbium oxide Yb 2 o 3 The amount of substance in Yb is 0.18mmol, erbium oxide Er 2 o 3 The amount of substance in Er is 0.02mmol;

[0064] b) Preparation of diethylene glycol-modified upconversion particles: Weigh 4mmol of NaF, put it in a 100mL round-bottomed flask, add 10mL of diethylene glycol, and heat it to 200oC with an oil bath under nitrogen protection and magnetic stirring. Add 12.5mL die...

Embodiment 3

[0073] 1) Preparation of water-soluble folic acid-functionalized upconversion particles:

[0074] a) Preparation of rare earth nitrates: 0.4 mmol yttrium oxide Y 2 o 3 , 0.09mmol ytterbium oxide Yb 2 o 3 , 0.01mmol erbium oxide Er 2 o 3 , that is, the ratio of the amount of yttrium, ytterbium, and erbium Y / Yb / Er=80 / 18 / 2, Y+Yb+Er=1mmol, weigh the mass, put it into a 50mL small beaker, add 2mL concentrated nitric acid, 4mL high-purity water , in a fume hood at 100oC, nitrify and evaporate to dryness; where Yttria Y 2 o 3 The amount of Y in the substance is 0.8mmol, ytterbium oxide Yb 2 o 3 The amount of substance in Yb is 0.18mmol, erbium oxide Er 2 o 3 The amount of substance in Er is 0.02mmol;

[0075] b) Preparation of diethylene glycol-modified upconversion particles: Weigh 4mmol NaF, put it in a 100mL round bottom flask, add 2mL diethylene glycol + 8mL high-purity water, and heat it to 160- 200oC, add 2.5mL diethylene glycol + 10mL high-purity water to the s...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of a composite material of water-soluble folic acid-functionalized up-converted nano particles (FA-UCNPs) and graphene oxide (GO). The preparation method mainly comprises the three steps of preparing FA-UCNPs, namely firstly, synthesizing diethylene glycol-modified up-converted nano particles (DEG-UCNPs), and secondly, synthesizing the FA-UCNPs; preparing GO, namely firstly, preliminarily oxidizing a graphite sheet, oxidizing, and synthesizing the GO which is good in water solubility, high in yield and adjustable in size; and preparing FA-UCNPs / GO, namely dispersing FA-UCNPs and GO with a weight ratio being 1 / 1-1 / 2, vibrating for 10min, and drying under the normal temperature in a vacuum condition, so as to obtain the FA-UCNPs / GO. The FA-UCNPs / GO prepared by adopting the method is good in water solubility and stability and can be used for identifying canceration cells as a biological probe, so that the composite material is very good in application prospect for early diagnosing of cancers.

Description

[0001] This patent is supported by the National Natural Science Foundation of China General Project 21375095, National Excellent Doctoral Dissertation Author Special Fund FANEDD-201023, Tianjin Applied Basic Research Program Key Project 12JCZDJC21700, Tianjin Universities "Young and Middle-aged Backbone Innovative Talents Training Program" ZX110GG015 and Tianjin Supported by the "Bohai Scholars" Project of Talent Introduction 5RL098 of Normal University. technical field [0002] The invention belongs to the field of preparation of fluorescent probe nanomaterials, in particular to a composite material of water-soluble folic acid-functionalized upconversion nanoparticles and graphene oxide and a preparation method thereof, which is mainly used for identifying cancerous cells. Background technique [0003] Rare earth ions have rich energy level structures and excellent optical properties. In recent years, rare earth doped upconversion nanomaterials have shown important applicati...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N21/64
Inventor 李妍胡悦立靳晴孙玉秀陈晓芳
Owner TIANJIN NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com