Preparation method of TTZ (thiotriazinone)
A technology of methylthiosemicarbazide and hydroxyl, which is applied in the field of preparation of cephalosporin intermediates, can solve the problems of difficult solvent recovery, unstable quality, large amount of waste water, etc., to reduce the cost of solvent recovery, reduce side reactions, and yield Improved effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0024] Add 2000kg of ethanol, 480kg of 2-methylthiosemicarbazide, 10kg of acetic acid, 100g of ammonium acetate, 21.6kg of catalyst boron tribromide, and 800kg of diethyl oxalate into the 5000L reactor. After the dropwise addition, heat up to 80°C Insulate for 4 hours, after the reaction, cool down to 15°C and filter to obtain the crude triazine ring (wet weight 10%) and mother liquor. Put the crude product into the refining reactor, add 2000kg of water, heat up to 78°C, add 1300kg of hydrochloric acid with a concentration of 30%, and cool down to 10 ℃, after centrifuge filter and dry, the finished product is 564kg, the yield is 77.63%, and the purity is 99.96%.
[0025] Gained mother liquor is applied mechanically 5 times continuously, and data is as follows:
[0026] Mother liquor cycle times Product weight / kg Product yield / % purity / % 0 564 77.63% 99.96% 1 570 78.35% 99.89% 2 567 78% 99.90% 3 567 78% 99.85% 4 565 77.75% 99.82...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com