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Applications of CO2 supercritical fluid extraction product of centipeda minima in preparation of anti-influenza virus medicines or food

A technology of supercritical extract and anti-influenza virus, which is applied in the field of medicine, can solve the problems that do not involve the anti-influenza virus of goose herbivore extract, and achieve good medical application value, good anti-influenza virus effect, high extraction efficiency effect

Active Publication Date: 2014-03-19
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, among the many research results, there is no report on whether the goose herbivore extract has the effect of anti-influenza virus

Method used

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  • Applications of CO2 supercritical fluid extraction product of centipeda minima in preparation of anti-influenza virus medicines or food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 300g goose does not eat herbs (collected from Guangdong, identified by Mai Zhenqiu, senior engineer of Guangzhou Medicinal Material Company as Compositae Coriander) Centipeda minima (L.) A. Br. et. Aschers, the same as in the following examples) dried whole grass or whole grass with flowers (same as in the following examples) crushed, passed through a 60-mesh sieve, and placed in CO 2 In the supercritical extraction apparatus, the extraction pressure was 25 MPa, the extraction temperature was 38 °C, the flow rate was 20 liters / hour, and the extraction time was 2 hours, to obtain the non-grazing CO. 2 Supercritical extract 20.3g.

Embodiment 2

[0031] 300g of dry whole grass (collected from Guangdong and identified by Mai Zhenqiu, senior engineer of Guangzhou Medicinal Material Company) was crushed, passed through a 60-mesh sieve, and placed in CO. 2 In the supercritical extraction apparatus, the extraction pressure was 40 MPa, the extraction temperature was 50 °C, the flow rate was 30 liters / hour, and the extraction time was 4 hours, to obtain the CO 2 Supercritical extract 22.6g.

Embodiment 3

[0033] 300g of dry whole grass (collected from Guangdong and identified by Mai Zhenqiu, senior engineer of Guangzhou Medicinal Material Company) was crushed, passed through a 60-mesh sieve, and placed in CO. 2 In a supercritical extraction apparatus, the extraction pressure was 20 MPa, the extraction temperature was 30 °C, the flow rate was 10 liters / hour, and the extraction time was 1 hour, to obtain the non-grazing CO. 2 Supercritical extract 14.6g.

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Abstract

The invention discloses applications of a CO2 supercritical fluid extraction product of centipeda minima in preparation of anti-influenza virus medicines or food. The extraction product of the centipeda minima is an extraction product obtained by utilization of a CO2 supercritical fluid extraction technology, or an extraction product which is obtained by subjecting the extraction product obtained by the CO2 supercritical fluid extraction technology to extraction and purification by petroleum ether, cyclohexane, chloroform or benzene. The extraction product of the centipeda minima has good anti-influenza virus functions. The antivirus function of the extraction product of the centipeda minima is equivalent to or more significant than that of positive control ribavirin. The extraction product of the centipeda minima has good medical application value. The applications provided by the invention provide a powerful technological base for development of the centipeda minima plant resource.

Description

technical field [0001] The present invention relates to the technical field of medicine, and more particularly, to a kind of CO 2 Application of supercritical extract in preparing medicine or food with anti-influenza virus effect. Background technique [0002] Influenza viruses are a major threat to human health. The respiratory disease caused by influenza virus is called influenza (flu), which has the characteristics of wide prevalence, strong infectivity and high morbidity. According to statistics, there are 600 to 1.2 billion influenza cases in the world each year, of which 3 million to 5 million cases of severe influenza and 250,000 to 500,000 deaths. The fatality rate of severe influenza can reach 10%. As a viral infectious disease, influenza not only seriously threatens the health of the people, but also brings a heavy burden to the country and society. How to effectively prevent and treat influenza, especially highly pathogenic influenza, has become an issue for cou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A23L1/29A23L2/38A61P31/16A23L33/00
Inventor 王国才李药兰李国强吴鹏张晓丽洪艺蕾
Owner JINAN UNIVERSITY
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