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Application of penehyclidine hydrochloride in the treatment of infectious toxic shock with microcirculation disturbance after comprehensive treatment measures such as blood volume supplementation

A technology for penehyclidine hydrochloride and microcirculation disorder, applied in the field of medicine, can solve the problems of careful blood transfusion, aggravating the burden on the patient's heart, and interfering with the coagulation mechanism.

Active Publication Date: 2016-05-11
JINZHOU AHON PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dextran can reduce blood viscosity, prevent thrombosis, reduce the occurrence of disseminated intravascular coagulation and improve microcirculation. It also has osmotic diuretic effect and prevents renal failure. Its adverse reactions are: allergic reactions may occur during the course of medication. For allergic reactions, the drug should be stopped in time. Excessive use can interfere with the coagulation mechanism and increase the burden on the patient's heart. It is contraindicated for bleeding disorders or thrombocytopenia
Whole blood and plasma can maintain effective blood volume, improve anemia and tissue hypoxia, avoid and improve organ dysfunction, but the blood transfusion process should be cautious

Method used

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  • Application of penehyclidine hydrochloride in the treatment of infectious toxic shock with microcirculation disturbance after comprehensive treatment measures such as blood volume supplementation
  • Application of penehyclidine hydrochloride in the treatment of infectious toxic shock with microcirculation disturbance after comprehensive treatment measures such as blood volume supplementation
  • Application of penehyclidine hydrochloride in the treatment of infectious toxic shock with microcirculation disturbance after comprehensive treatment measures such as blood volume supplementation

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Experimental program
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Embodiment Construction

[0031] Application test of penehyclidine hydrochloride in the treatment of infectious toxic shock with microcirculation disturbance after comprehensive treatment measures such as blood volume supplementation.

[0032] Experimental Materials

[0033] 1.1.1 Experimental drugs

[0034] Penehyclidine Hydrochloride Injection (Changtuoning): Anticholinergic, anti-shock treatment. Specifications: 1ml: 1mg. Provided by Chengdu Lisite Pharmaceutical Co., Ltd., the batch number is 111201. Clinical intravenous injection, the first dose is 6 mg, and then 2 mg is given every 12 hours according to the situation for maintenance, and the total dose is 10 mg / d.

[0035] The adult clinical dosage referred to in this experiment is 0.1667mg / kg·d (10mg / 60kg·d), according to the conversion formula of human and animal dosage A=kW 2 / 3 / 10000 is calculated, the dose of rabbit is 0.3632mg / kg·d, the drug is diluted with normal saline, the concentration is 0.018162mg / ml, and the administration vol...

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Abstract

The invention discloses the application of penehyclidine hydrochloride in the treatment of septic shock in which microcirculation disturbance still exists after comprehensive treatment measures such as replenishing blood volume. Infection toxic shock referred to in the present invention refers to the shock caused by bacterial attack, and the effect of the present invention is proved by the effect of penhyclidine hydrochloride aqueous solution on microcirculation disorder caused by infectious toxic shock in rabbits.

Description

technical field [0001] The present invention belongs to the field of pharmaceuticals, and specifically relates to the new medical application of penehyclidine hydrochloride, especially the application of penehyclidine hydrochloride in the treatment of infection, toxic shock, and microcirculation disturbance after comprehensive treatment measures such as blood volume supplementation. The infectious shock mentioned above refers to the shock caused by bacterial attack. Background technique [0002] Penehyclidine hydrochloride, English name PenehyclidineHydrochloride, chemical name 3-(2-cyclopentyl-2-hydroxy-2-phenylethoxy)quinuclidine hydrochloride, molecular formula C 20 h 29 NO 2 • HCl, molecular weight 351.92. [0003] Penehyclidine hydrochloride is a new type of anticholinergic drug with selective M 1 , M 3 and N 1 , N 2 Receptor antagonism, has a strong anticholinergic effect on the central and peripheral, and has a strong anticholinergic effect on M 2 The receptor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/439A61P9/08
Inventor 黄绍渊张浩樊昊梁慧容
Owner JINZHOU AHON PHARM CO LTD
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