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Extraction method for plane tree bark polysaccharide

A technology for extracting polysaccharides from sycamore bark, which is applied in the direction of drug combination and antineoplastic drugs to achieve the effect suitable for production and low cost

Inactive Publication Date: 2014-03-12
CHIFCON DRUG DISCOVERY SUZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] In the prior art, people usually use the bark of the sycamore plant sycamore to extract betulinic acid components. Generally, organic solvents such as ethyl acetate, dichloromethane, or ethanol are used, and then the filter residue is disposed of as waste, but There is also a polysaccharide component that has been neglected, but this polysaccharide component has a broad-spectrum inhibitory effect on tumor growth

Method used

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Embodiment

[0010] In this embodiment, a method for extracting polysaccharides from sycamore bark, using organic solvent treatment and extracting betulinic acid and other components of sycamore bark medicinal material residues to extract polysaccharide components, including the following steps, step 1, drying the medicinal material residues , use cold water to soak overnight, the liquid surface is not over the medicinal material residue; step 2, filter, collect the filtrate, use 50-60 degrees Celsius hot water to heat and soak the filter residue 2 times, each time for 3-6 hours, and combine the filtrate 3 times; step 3 , Concentrate the filtrate obtained in Step 2 under reduced pressure to a slurry, add 95% ethanol until the alcohol content of the concentrated solution is 78% to 82%, and let it stand for more than 8 hours. Step 4: Suction filtration, rinse the filter residue with acetone three times, and dry the filter residue , that is, much sugar.

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Abstract

The invention provides an extraction method for plane tree bark polysaccharide. Plane tree bark medicinal material residues after processing of organic solvents and extraction of components of betulinic acid and the like are employed for extraction of polysaccharide components. The method comprises the following steps: first, the medicinal material residues are dried in the sun, soaked in cold water for overnight, and the liquid level exceeds the medicinal material residues; second, filtration is carried out, the filtrate is collected, the filter residues are heated and soaked in warm water with a temperature of 50-60 DEG C twice, each time is for 3-6h, and the three filtrates are mixed; third, the mixed filtrate obtained from the second step is subjected to pressure reduction concentration until a slurry is formed, 95% of ethanol is added until the content of ethanol in the concentrated solution is 78%-82%, and the mixture is permitted to stand for above 8h; fourth, pumping filtration is carried out, the filter residues are washed with acetone for three times, and dried, and the polysaccharide is obtained. The method makes good use of waste materials of plane tree barks after extraction of betulinic acid, and polysaccharide components with strong antineoplastic activity are extracted. The method is suitable for production and has low cost.

Description

technical field [0001] The invention relates to the field of natural products, in particular to a method for extracting sycamore bark polysaccharides. Background technique [0002] In the prior art, people usually use the bark of the sycamore plant sycamore to extract betulinic acid components. Generally, organic solvents such as ethyl acetate, dichloromethane, or ethanol are used, and then the filter residue is disposed of as waste, but There is also a polysaccharide component that has been neglected, but this polysaccharide component has a broad-spectrum inhibitory effect on tumor growth. Contents of the invention [0003] In view of the defects in the above-mentioned prior art, the purpose of the present invention is to propose a method for extracting polysaccharides from sycamore bark, and utilize waste to develop a bulk drug with tumor suppressor activity. [0004] The purpose of the present invention will be achieved through the following technical solutions: [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61P35/00
Inventor 沈金辉
Owner CHIFCON DRUG DISCOVERY SUZHOU
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