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Chinese medicinal ethosome gel patch for treating herpes zoster and preparation method thereof

A gel patch and herpes zoster technology, applied in the field of medicine, can solve the problems of unclear pathogenesis, unsatisfactory curative effect, impact on quality of life and the like, and achieve good curative effect, good social and economic benefits, and analgesia. strong effect

Inactive Publication Date: 2015-04-22
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pathogenesis of this disease is not very clear, clinical treatment is very difficult, patients not only have abnormal pain, but also restless day and night, difficulty falling asleep, accompanied by unbearable itching from time to time, which seriously affects the quality of life
Western medicine includes systemic medication, topical medication, nerve block, physical therapy, etc. It mainly focuses on symptomatic treatment, and the curative effect is not very satisfactory.

Method used

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  • Chinese medicinal ethosome gel patch for treating herpes zoster and preparation method thereof
  • Chinese medicinal ethosome gel patch for treating herpes zoster and preparation method thereof
  • Chinese medicinal ethosome gel patch for treating herpes zoster and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1. Weigh 1 kg of licorice, crush it, add 10 times the amount of 30% ethanol, add ammonia to adjust the pH to 8.9, reflux at 85°C for 2 hours, immediately filter out the medicinal residue with three layers of gauze, and recover the filtrate while it is hot through a 0.45 μm filter membrane Ethanol to obtain water solution 1; add 8 times the amount of 30% ethanol to the dregs, add ammonia water to adjust the pH to 9.1, reflux at 80°C to 90°C for 1 hour, immediately filter out the dregs with three layers of gauze, and filter the filtrate through 0.45 μm while it is hot The ethanol was recovered after the film to obtain the aqueous liquid 2; the aqueous liquid 1 and the aqueous liquid 2 were combined, and concentrated in a vacuum to obtain 0.1721 kg of licorice extract, containing 0.1009 kg of glycyrrhizic acid and 0.0424 kg of water.

[0015] 2. First add 10kg of absolute ethanol to the mixture of 0.69kg of soybean lecithin and 0.0052kg of cholesterol, stir and dissolve, ad...

Embodiment 2

[0021] 1. Weigh 2kg of licorice, crush it, add 10 times the amount of 30% ethanol, add ammonia water to adjust the pH to 8.6, reflux at 85°C for 2 hours, immediately filter out the medicinal residue with three layers of gauze, and recover the filtrate while it is hot through a 0.45μm filter membrane Ethanol to obtain water solution 1; add 8 times the amount of 30% ethanol to the medicinal residue, add ammonia water to adjust the pH to 9.2, reflux at 90°C for 1 hour, immediately filter the medicinal residue with three layers of gauze, and recover the filtrate while it is hot through a 0.45 μm filter membrane Ethanol was used to obtain water solution 2; water solution 1 and water solution 2 were combined, and concentrated in a vacuum to obtain 0.2836 kg of licorice extract, containing 0.2369 kg of glycyrrhizic acid and 0.0618 kg of water.

[0022] 2. First add 17kg of absolute ethanol to the mixture of 1.1kg of soybean lecithin and 0.0085kg of cholesterol, stir and dissolve, add ...

Embodiment 3

[0028] Embodiment 3: pharmacodynamic research

[0029] 1. Research object

[0030] The selected subjects were all outpatients from the Dermatology Department of the Affiliated Hospital of Yangzhou University. There were 63 cases in the Chinese medicine patch treatment group, 31 cases (1 case fell off), and the control group 32 cases (1 case fell off). All enrolled patients signed the informed notice.

[0031] 2. Diagnostic criteria

[0032] Referring to Dermatology and Venereology published by People's Health Publishing House in 2008:

[0033] (1) Systemic symptoms such as mild fatigue, low-grade fever, and anorexia before eruption;

[0034] (2) The skin of the affected area feels hot or painful, and there is obvious pain sensitivity when touched;

[0035] (3) Predilection sites are the innervated areas of intercostal nerves, cervical nerves, bigeminal nerves and lumbar bones;

[0036] (4) Skin lesions often appear first as flushed spots, and soon appear miliary to soybea...

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Abstract

The invention discloses a Chinese medicinal ethosome gel patch for treating herpes zoster. The Chinese medicinal ethosome gel patch is characterized in that a therapeutic ingredient of the patch is a Chinese medicinal composition, wherein emulsion type polyacrylate is used as a pressure sensitive adhesive; the Chinese medicinal composition consists of the following materials in percentage by weight: 30 percent of liquoric root ethosome, 60 percent of water mixed decoction of gentian, white paeony root, Chinese thorowax root, angelica, root of rehmannia, szechuan lovage rhizome and szechwan chinaberry fruit, 2 percent of polyvinyl alcohol, 1 percent of gardenia, 3 percent of frankincense, 1 percent of indigo naturalis and 3 percent of borneol. The pharmacodynamics study of the patch shows that the patch has a good therapeutic effect on the early-to-mid herpes zoster and especially has better effects of shortening the course of disease, promoting deflorescence and relieving local pain. The patch is easy in medication and convenient to use, has a good therapeutic effect, quick response, strong analgesic action but no adverse reaction, and brings good social benefit and economic benefit after development and application.

Description

technical field [0001] The invention relates to a traditional Chinese medicine ethosome gel patch for treating herpes zoster and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Herpes zoster is a clinically more common acute herpetic skin disease, caused by chickenpox and herpes zoster virus, and usually occurs in spring. To the treatment of this disease, ribavirin, indomethacin and vitamin drugs are commonly used in modern medicine, but the curative effect is far from ideal. Herpes zoster is a curable disease, but after the herpes zoster subsides, the affected area remains for a long time, which is called postherpetic neuralgia (PHN), and it is difficult to treat. The incidence of this disease is higher in elderly patients, and the clinical symptoms are severe, and the pain often lasts for several months or even years. The pathogenesis of this disease is not very clear, and clinical treatment is very difficult. Pat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61K9/70A61P31/22A61K31/045
Inventor 卜平胡荣陈琳卫榕吴欢欢黄晓丽
Owner YANGZHOU UNIV
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