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Method for improving stability of magnetic nanoparticle contrast agent

A technology of contrast agent stability and magnetic nanometer, applied in the field of magnetic nanometer contrast agent, can solve the problems of reduced contrast agent contrast ability, weakened saturation magnetization, influence of nuclear magnetic imaging effect, etc. simple method effect

Active Publication Date: 2014-01-22
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the iron oxide magnetic nano contrast agent itself is unstable, and it is easy to be further oxidized in aqueous solution, resulting in weakened saturation magnetization, which reduces the imaging ability of the contrast agent and affects the effect of nuclear magnetic imaging.

Method used

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  • Method for improving stability of magnetic nanoparticle contrast agent

Examples

Experimental program
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Effect test

Embodiment 1

[0029] (1) Preparation of magnetic nanoparticles

[0030] Add sodium citrate and ferric chloride into the beaker, then add ethylene glycol and diethylene glycol, after ultrasonic dissolution, add sodium acetate, further ultrasonic dissolution, and finally transfer to the reaction kettle, under the condition of 200 degrees, react for 10 Hours, the magnetic nanoparticles were obtained after washing three times with deionized water.

[0031] (2) Polydopamine-coated magnetic nanoparticles

[0032] Disperse 0.4g of nanoparticles into 4 liters of alkaline buffer solution, dissolve 1.2g of dopamine hydrochloride in 100ml of water, mix the two, stir for 2 hours, centrifuge and wash with deionized water to obtain Magnetic nanoparticles coated with polydopamine with a thickness of 15 nm are called contrast agent 1.

[0033] figure 1 For the prepared magnetic nanoparticles, it can be seen from TEM pictures that the particle diameter of the magnetic nanoparticles is between 50-80nm. ...

Embodiment 2

[0036] (1) The preparation of magnetic nanoparticles is the same as in Example 1.

[0037] (2) Disperse 0.4g of nanoparticles into 4 liters of alkaline buffer solution, dissolve 1g of dopamine hydrochloride in 100ml of water, then mix the two, stir for 2 hours, centrifuge, and wash with deionized water three times , that is, magnetic nanoparticles coated with polydopamine with a thickness of 12 nm, called contrast agent 2.

Embodiment 3

[0039] (1) The preparation of magnetic nanoparticles is the same as in Example 1.

[0040] (2) Disperse 0.4g of nanoparticles into 4 liters of alkaline buffer solution, dissolve 0.8g of dopamine hydrochloride in 100ml of water, then mix the two, stir for 2 hours, centrifuge and wash with deionized water Three times to obtain magnetic nanoparticles coated with polydopamine with a thickness of 8 nm, which is called contrast agent 3.

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Abstract

The invention relates to a method for improving the stability of a magnetic nanoparticle contrast agent. The method comprises the following step: coating the magnetic nanoparticles with poly dopamine. The invention adopts a simple and green synthesis method to obtain the magnetic nanoparticles coated with poly dopamine. The employed raw materials are cheap and easily available; and the synthesis method is simple. The method provided by the invention realizes controllable coating on thickness of magnetic nanoparticles by simply controlling the weight ratio of magnetic nanoparticles and dopamine hydrochloride.

Description

technical field [0001] The invention relates to the technical field of magnetic nano-contrast agents, in particular to a method for improving the stability of magnetic nano-contrast agents. Background technique [0002] Magnetic resonance imaging (MRI) technology is a very important diagnostic tool in clinical medicine. Magnetic nano-contrast agents based on iron oxides (mainly Fe 3 o 4 , γ-Fe 2 o 3 ) can effectively shorten the transverse relaxation time (T 2 ), thus considered to be one of the most promising MRI contrast agents. [0003] However, the iron oxide magnetic nano contrast agent itself is unstable, and it is easily further oxidized in aqueous solution, resulting in weakened saturation magnetization, which reduces the imaging ability of the contrast agent and affects the effect of nuclear magnetic imaging. Contents of the invention [0004] The present invention aims to solve the technical problem of how to effectively maintain the stability of iron oxide...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/12
Inventor 艾可龙刘艳岚逯乐慧
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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