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Preparing method and application of bone setting zijin pills

A technology of bone-setting Zijin pills and lotus seeds is applied in the field of preparation of bone-setting Zijin pills, which can solve the problems of large dosage, many impurities and backwardness of patients, and achieve the effect of reducing the dosage.

Inactive Publication Date: 2014-01-22
泰州市高科新技术开发中心高港区知识产权咨询事务所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Zhenggu Zijin Pills. However, the method of making powder is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the quality of this product. clinical application

Method used

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  • Preparing method and application of bone setting zijin pills
  • Preparing method and application of bone setting zijin pills

Examples

Experimental program
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Effect test

Embodiment 1

[0016] Take 50g cloves, 100g lotus seeds, 50g cooked rhubarb, 50g catechu, fried white peony 100g, dragon blood 50g, tree peony bark 25g, angelica 100g, woody 50g, poria cocos 100g, safflower 50g, licorice 15g, and add to CO2 supercritical In the extractor, ethanol is used as the entrainer, the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 15MPa, the temperature is 30℃, and CO 2 The flow rate is 1m1 / g crude drug·min, and the extraction time is 150min. The supercritical extract powder is obtained, crushed into fine powder, sieved, and mixed. Add 100g of refined honey per 100g to make big honey pill, which is 4.5g per pill.

Embodiment 2

[0018] Take 50g cloves, 100g lotus seeds, 50g cooked rhubarb, 50g catechu, fried white peony 100g, dragon blood 50g, peony bark 25g, angelica 100g, woody 50g, poria cocos 100g, safflower 50g, licorice 15g and add to CO 2 In the supercritical extractor, ethanol is used as the entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract powder is obtained, crushed into fine powder, sieved, and mixed. Add 110g of refined honey per 100g to make big honey pill, which is 4.5g per pill.

Embodiment 3

[0020] Take 50g cloves, 100g lotus seeds, 50g cooked rhubarb, 50g catechu, fried white peony 100g, dragon blood 50g, peony bark 25g, angelica 100g, woody 50g, poria cocos 100g, safflower 50g, licorice 15g and add to CO 2 In the supercritical extractor, ethanol is used as the entrainer. The entrainer accounts for 5% of the total extraction solvent. The extraction pressure is 20MPa, the temperature is 40°C, and CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract powder is obtained, crushed into fine powder, sieved, and mixed. Add 100g of refined honey per 100g to make big honey pill, which is 4.5g per pill.

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Abstract

The invention provides a preparing method of bone setting zijin pills. Cloves of 50g, lotus nuts of 100g, cooked rhubarb of 50g, catechu of 50g, stir-baked white paeony roots of 100g, sanguis draconis of 50g, moutan bark of 25g, Chinese angelica of 100g, elecampane of 50g, poria cocos of 100g, flos carthami of 50g and liquorice of 15g are used as raw materials to prepare the bone setting zijin pills. The bone setting zijin pills are formed through supercritical extraction, so that the content is greatly improved, and the dose is lowered. The invention further provides an application of the bone setting zijin pills in preparing medicine for inhibiting mice leukemia L1210 cell proliferation.

Description

Technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Zhenggu Zijin Pills. Background technique [0002] Zhenggu Zijin Pills are recorded in the drug standard WS3-B-0050-89 issued by the Ministry of Health. The prescription is clove 50g, lotus seed 100g, cooked rhubarb 50g, catechu 50g, fried white peony 100g, dragon's blood 50g, tree peony skin 25g, angelica 100g, Woody 50g, Poria 100g, Safflower 50g, Licorice 15g, the above twelve flavors, crushed into fine powder, sieved, and mixed; each 100g powder is added with 100-110g refined honey to make a big honey pill. It can promote blood circulation, dissipate blood stasis, reduce swelling and relieve pain. Used for traumatic injuries, blocked meridians, blood stasis, swelling and pain. [0003] In the prior art, there has not been a report on the use of supercritical technology in the extraction and preparation of Zh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K36/889A61K9/20A61P35/02
Inventor 张关莲
Owner 泰州市高科新技术开发中心高港区知识产权咨询事务所
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