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Application of N-acetylcysteine in preparation of drugs for preventing and treating DNA damage and tissue damage induced by synchrotron radiation

A DNA damage, cysteine ​​technology, used in antioxidant drugs in the field of pharmacy

Inactive Publication Date: 2014-01-15
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Except for the reported NAD+ can reduce the DNA damage and tissue damage of gonads and other tissues induced by synchrotron radiation X-rays, there is no other method to reduce the tissue damage induced by synchrotron radiation X-rays

Method used

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  • Application of N-acetylcysteine in preparation of drugs for preventing and treating DNA damage and tissue damage induced by synchrotron radiation
  • Application of N-acetylcysteine in preparation of drugs for preventing and treating DNA damage and tissue damage induced by synchrotron radiation
  • Application of N-acetylcysteine in preparation of drugs for preventing and treating DNA damage and tissue damage induced by synchrotron radiation

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Embodiment Construction

[0020] The present invention mainly includes the following aspects to the experimental content of the application of NAC in the preparation and prevention of synchrotron radiation-induced DNA damage and tissue medicine:

[0021] 1. NAC has a protective effect on double-strand DNA damage in the testes of rats irradiated by synchrotron radiation X-rays.

[0022] 2. NAC has a protective effect on the tissue damage of the testes of rats irradiated by synchrotron radiation X-rays.

[0023] The application of NAC in the preparation of drugs for preventing and treating DNA damage and tissue induced by synchrotron radiation is further illustrated through pharmacodynamic experiments.

[0024] 1. Experimental method

[0025] 1. Animal operation and synchrotron radiation X-ray radiation process

[0026] Our research is using male SD rats, weighing between 190-220g, at the BL13W line station of Shanghai Synchrotron Radiation Light Source. All operating procedures are in compliance with...

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Abstract

The invention relates to an application of an antioxidant drug in the pharmaceutical science field, and especially relates to an application of N-acetylcysteine in preparation of drugs for preventing and treating gonads and other tissue DNA damage and tissue damage induced by synchrotron radiation X-rays. According to experimental results, N-acetylcysteine is indicated to be capable of protecting the double-strand DNA damage caused by synchrotron radiation X-ray radiation, and protecting testicular seminiferous tubule cell layer number reduction caused by the synchrotron radiation X-ray radiation; and the antioxidant is indicated to have important application value in the preparation of the drugs for preventing and treating the synchrotron radiation damage.

Description

technical field [0001] The present invention relates to the application of antioxidant drugs in the field of pharmacy, especially the application of N-acetyl-L-cysteine ​​in the preparation of drugs for the prevention or treatment of DNA damage and tissue damage in gonads and other tissues induced by synchrotron radiation X-rays . Background technique [0002] The chemical structural formula of N-acetyl-L-cysteine ​​(N-acetylcysteine, NAC for short) is: [0003] [0004] The preparation method of NAC is mainly to use L-cysteine ​​and acetic anhydride as raw materials, carry out acylation reaction to obtain a crude product, and refine it with activated carbon and ether to obtain a finished product. [0005] Synchrotron X-ray-based microbeam radiation therapy could be a new approach to treating cancers such as glioma. And synchrotron X-ray-based medical imaging can provide ultra-high-resolution images. Therefore, synchrotron radiation X-rays may have important clinical a...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61P39/06A61P5/00
Inventor 殷卫海马英鑫聂辉盛财滨陈贺愈王班夏伟梁
Owner SHANGHAI JIAO TONG UNIV
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