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Application of dihydrogen porphin titanium complex in preparation of drug for treating tumor

A technology of phenetitanium compounds and tumor drugs, which is applied in the field of tumor treatment, can solve problems such as poor water solubility, difficulty in human body absorption, unsatisfactory tumor killing effect, etc., achieve excellent effects and improve the effect of action

Inactive Publication Date: 2013-12-18
刘辉
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  • Abstract
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Problems solved by technology

Although the second-generation photosensitizer has made considerable progress, it still has the following defects: poor water solubility, difficulty in human body absorption, low tumor targeting, unsatisfactory light absorption rate, and unsatisfactory specific absorption wavelength of light that penetrates human tissues. Limited permeability, low yield of singlet oxygen, unsatisfactory killing effect on tumors, easy to be oxidized and degraded by oxygen in the air, which is not conducive to storage

Method used

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  • Application of dihydrogen porphin titanium complex in preparation of drug for treating tumor
  • Application of dihydrogen porphin titanium complex in preparation of drug for treating tumor
  • Application of dihydrogen porphin titanium complex in preparation of drug for treating tumor

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Embodiment Construction

[0034] The preparation method of chlorin titanium compound

[0035] Using chlorin e6 monomer as a synthetic material, dissolve 20g of chlorin e6 (Chlorin e6, Ce6) in 500mL of ethanol, (after fully dissolving, irradiate with red light with a wavelength of 660nm for 20min under the protection of a nitrogen atmosphere , and heated to 70 °C to activate chlorin.

[0036] Dissolve analytically pure TiCl2 in deionized water under a nitrogen protective atmosphere and adjust the pH of the solution to 8.2, add activated chlorphine, and stir slowly in the dark to synthesize chlorphine e6 titanium compound. After the synthesis was completed, the chlorin titanium compound was added into absolute ethanol, and stirred slowly for 24 hours at 50° C. in the dark under the protection of nitrogen to obtain a stable chlorin e6 titanium compound.

[0037] The H NMR detection result of chlorin titanium compound is as follows figure 1 As shown, its UV-visible spectrum is shown as figure 2 As show...

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Abstract

The invention discloses application of a dihydrogen porphin titanium complex in preparation of a drug for treating tumor. Compared with dihydrogen porphin, the drug disclosed by the invention has a better treatment effect.

Description

technical field [0001] The invention relates to the technical field of tumor treatment, in particular to the application of chlorinated titanium compound in the preparation of tumor treatment drugs. Background technique [0002] Photodynamic therapy (Photodynamic treatment, PDT) is a new tumor treatment method that emerged in the 20th century. With the development of high-power laser generators and photosensitizers, PDT has become a tumor treatment option in addition to surgery, radiotherapy, and chemotherapy. The 4th effective therapy. PDT treatment of tumors needs to include four elements at the same time: matrix, photosensitizer, oxygen, and laser. The photosensitizer is the core factor of PDT treatment, and its photosensitivity directly determines the therapeutic effect of PDT on tumors. At present, photosensitizers have entered the research and development of the second generation of photosensitizers. The earliest photosensitizers used in PDT were hematoporphyrin deri...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K31/409A61P35/00
Inventor 文剑陈志强刘辉
Owner 刘辉
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