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Anti-hair loss Chinese herbal medicine compound for inhibiting 5α-reductase activity and preparation method thereof

A technology for preventing hair loss and reductase, which can be used in pharmaceutical formulations, hair care, drug combinations, etc., can solve the problems of large irritation and side effects of western medicine ingredients, and achieves increased scalp blood microcirculation, low production cost, and simple preparation. Effect

Active Publication Date: 2016-06-29
GUANGZHOU TIANWEN JIAOYAN COSMETICS
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Problems solved by technology

However, the ingredients of western medicine are highly irritating and have great side effects, so the development of natural 5α-reductase inhibitors has been paid more and more attention

Method used

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  • Anti-hair loss Chinese herbal medicine compound for inhibiting 5α-reductase activity and preparation method thereof
  • Anti-hair loss Chinese herbal medicine compound for inhibiting 5α-reductase activity and preparation method thereof
  • Anti-hair loss Chinese herbal medicine compound for inhibiting 5α-reductase activity and preparation method thereof

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preparation example Construction

[0031] The preparation method of the anti-hair loss Chinese herbal medicine compound that inhibits 5α-reductase activity of Examples 9 to 11 in Table 2 is specifically: extracting saw palmetto extract, bayberry bark extract, arborvitae extract, angelica extract, anemarrhena Extract, Prunella vulgaris extract, Ginger extract, Sophora flavescens extract, Pineapple extract, Schisandra fruit extract, Kaempferia extract are mixed according to the consumption of corresponding embodiment in Table 2, can obtain corresponding anti-hair loss Chinese herbal medicine compound; The preparation steps of each Chinese herbal medicine extract are as follows: pulverize the corresponding Chinese herbal medicine, soak the pulverized Chinese herbal medicine in pure water under normal pressure for 15 days, and the soaking extraction temperature is 35°C; filter the mixed solution obtained after soaking, and filter the obtained filtrate Concentrate at 60°C to obtain the corresponding Chinese herbal me...

Embodiment 23

[0042] The preparation steps of each Chinese herbal medicine extract in Example 23 and Example 24 include: pulverizing the corresponding Chinese herbal medicine, soaking the pulverized Chinese herbal medicine in 70% (mass percentage) ethanol under negative pressure for 7 days, and the soaking extraction temperature is 20 °C; filter the mixed solution obtained after soaking, and concentrate the obtained filtrate at 40 °C to obtain the corresponding Chinese herbal medicine extract.

Embodiment 25

[0043] The preparation steps of each Chinese herbal medicine extract in Example 25 and Example 26 are as follows: pulverize the corresponding Chinese herbal medicine, soak the pulverized Chinese herbal medicine in pure water under normal pressure for 15 days, and the soaking extraction temperature is 35° C.; filter and soak to obtain Concentrate the obtained filtrate at 60°C to obtain the corresponding Chinese herbal medicine extract.

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Abstract

The invention discloses a Chinese herbal medicine compound for preventing hair loss by inhibiting the activity of 5α-reductase, which belongs to the pharmaceutical composition. It contains saw palmetto extract, bayberry bark extract, arborvitae extract, angelica extract, anemarrhena extract, prunella vulgaris extract, ginger extract, sophora flavescens extract, pineapple extract, Schisandra fruit extract , Kaempferia extract, wherein each Chinese herbal medicine extract accounts for 0.1-99% by weight of the total amount of the anti-hair loss Chinese herbal medicine compound. The anti-hair loss Chinese herbal medicine compound of the invention is used for treating seborrheic alopecia symptoms caused by male androgen.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing hair loss, in particular to a Chinese herbal medicine compound for preventing hair loss which inhibits the activity of 5α-reductase; the invention also relates to a preparation method of the Chinese herbal medicine compound for preventing hair loss. Background technique [0002] Seborrheic alopecia (seborrheic alopecia, SA), also known as male pattern alopecia (malepatternalopecia, MPA), androgenetic alopecia (Androgenetic alopecia, AGA), mostly occurs in middle-aged and young men, and about 25-40 years old adult men There is 1 / 3 hair loss of varying degrees. Although the patient had no obvious symptoms, he urgently required treatment because of the impact on the appearance. [0003] Head hair is strictly affected by androgen. The main androgen in men is testosterone, which can be metabolized into dihydrotestosterone (DHT) under the action of 5α-reductase (5α-R). This change is irrev...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K8/97A61P17/14A61Q5/12A61Q5/02
Inventor 吴培诚欧春凤梁高卫邹宏图刘伟成周磊姚中华
Owner GUANGZHOU TIANWEN JIAOYAN COSMETICS
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