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Application of arctigenin to preparing medicaments for treating systemic lupus erythematosus

A technique for arctigenin and lupus erythematosus, which is applied in the field of medicine, can solve the problems such as no reported use of arctigenin in lupus erythematosus, etc., and achieves the effects of correcting abnormal immune function, fast onset of effect and price advantage.

Active Publication Date: 2013-12-04
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been proved that arctigenin has stronger biological activity than arctiin, such as significant antibacterial, antiviral, antitumor, anti-PAF receptor and calcium antagonistic activities, but arctigenin has not been reported in the prior art Use in the preparation of medicines for treating systemic lupus erythematosus

Method used

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  • Application of arctigenin to preparing medicaments for treating systemic lupus erythematosus
  • Application of arctigenin to preparing medicaments for treating systemic lupus erythematosus
  • Application of arctigenin to preparing medicaments for treating systemic lupus erythematosus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 arctigenin injection

[0020] prescription:

[0021] Arctigenin 4g

[0022] PEG-400 200ml

[0023] Add 0.9% sodium chloride solution to 1000ml

[0024] Preparation Process:

[0025] Add the prescribed amount of PEG-400 to arctigenin, stir to dissolve, add the prescribed amount of 0.9% sodium chloride solution to 1000ml, stir evenly, adjust the pH to 3, add 0.5% activated carbon for needles, stir, and decarbonize, that is have to.

Embodiment 2

[0026] Embodiment 2 arctigenin injection

[0027] prescription:

[0028] Arctigenin 5g

[0029] PEG-300 300ml

[0030] Add 0.9% sodium chloride solution to 1000ml

[0031] Preparation Process:

[0032] Add the prescribed amount of PEG-300 to arctigenin, stir to dissolve, add 0.9% sodium chloride solution to 1000ml, stir evenly, adjust the pH to 4, add 0.5% activated carbon for needles, stir, decarbonize, and the product is ready. Embodiment 3 arctigenin injection

Embodiment 3

[0032] Add the prescribed amount of PEG-300 to arctigenin, stir to dissolve, add 0.9% sodium chloride solution to 1000ml, stir evenly, adjust the pH to 4, add 0.5% activated carbon for needles, stir, decarbonize, and the product is ready. Embodiment 3 arctigenin injection

[0033] prescription:

[0034] Arctigenin 4g

[0035] PEG-400 100ml

[0036] Add water for injection to 1000ml

[0037] Preparation Process:

[0038] Add the prescribed amount of PEG-400 to arctigenin, stir to dissolve, add water for injection to 1000ml, stir evenly, adjust the pH to 5 with citric acid, add 0.5% activated carbon for needles, stir, decarbonize, and the product is ready.

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PUM

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Abstract

The invention belongs to medicine field, and specifically relates to an application of arctigenin to preparing medicaments for treating systemic lupus erythematosus (SLE). Arctigenin is capable of effectively lymphocyte dysfunction of SLE mise and secretion unbalance of multiple cytokines, has substantial treatment effect on systemic lupus erythematosus, and has the potential of being exploited into the medicaments for treating systemic lupus erythematosus.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of arctigenin in the preparation of medicines for treating systemic lupus erythematosus. Background technique [0002] Systemic lupus erythematosus (SLE) is a diffuse, systemic autoimmune disease that mainly affects the skin and mucous membranes, skeletal muscles, kidneys, and central nervous system, and may also affect multiple organs such as the lungs, heart, and blood. And system, showing a variety of clinical manifestations, its etiology and pathogenesis are not yet clear, a variety of autoantibodies and immunological abnormalities can be detected in the serum of patients with systemic lupus erythematosus, abnormal lymphocyte function and imbalance of secretion of various cytokines in patients with systemic lupus erythematosus It plays an important role in the occurrence and development of the disease. Studies have confirmed that the CD3+CD4+T cells in the peripher...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P19/04A61P37/02
Inventor 赵志全徐真真李斌
Owner LUNAN PHARMA GROUP CORPORATION
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