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Adapalene gel and method for preparing same

A gel and prescription technology, which is applied in the field of pharmaceutical preparations, can solve problems such as fundamentally avoiding contact between adapalene and aluminum packaging materials, lowering blood calcium levels, and hidden dangers of drug safety, so as to facilitate long-term storage and transportation , good transdermal absorption and safe medication

Active Publication Date: 2013-12-04
江苏小林制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the above techniques can alleviate the reaction between adapalene and metal ions in the medium, it cannot fundamentally avoid the contact between adapalene and aluminum packaging materials
In addition, preparations containing metal ion chelating agents have hidden dangers in medication safety, because edetate disodium can lower blood calcium levels, and edetate calcium sodium can cause some patients to have transient dizziness, nausea, joint acidity, fatigue and other reactions

Method used

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  • Adapalene gel and method for preparing same
  • Adapalene gel and method for preparing same
  • Adapalene gel and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 Adapalene gel prescription and preparation technology thereof

[0028]

[0029] Preparation Process:

[0030] (1) Prescription quantity Weigh adapalene, Tween 80, and sodium benzoate, add them to a certain amount of water, stir to dissolve, and obtain solution Ⅰ;

[0031] (2) Dissolve hydroxypropyl methylcellulose E5 in water to obtain solution II;

[0032] (3) Mix solution I and solution II, stir evenly, and add water to the full amount.

Embodiment 2

[0033] Embodiment 2 Adapalene gel prescription and preparation technology thereof

[0034]

[0035] Preparation Process:

[0036] (1) Prescription quantity Weigh adapalene, Tween 80, and sodium benzoate, add them to a certain amount of water, stir to dissolve, and obtain solution Ⅰ;

[0037] (2) Dissolve hydroxypropyl methylcellulose E5 in water to obtain solution II;

[0038] (3) Mix solution I and solution II, stir evenly, and add water to the full amount.

Embodiment 3

[0039] Embodiment 3 Adapalene gel prescription and preparation technology thereof

[0040]

[0041] Preparation Process:

[0042] (1) Prescription quantity Weigh adapalene, Tween 80, and sodium benzoate, add them to a certain amount of water, stir to dissolve, and obtain solution Ⅰ;

[0043] (2) Dissolve hydroxypropyl methylcellulose E5 in water to obtain solution II;

[0044] (3) Mix solution I and solution II, stir evenly, and add water to the full amount.

[0045] Following is the embodiment of failure in the test of the present invention:

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Abstract

The invention discloses adapalene gel and a method for preparing the same. The adapalene gel which is a preparation comprises adapalene and accessories. The adapalene is an active ingredient, and the accessories include hydroxypropyl methyl celluloses E5 and tween 80. The adapalene gel and the method have the advantages that the hydroxypropyl methyl celluloses E5 are added into a formula and can replace carbomer to be used as a gel base material, the adapalene can be isolated and prevented from being in contact with packing materials of the gel owing to a film forming property of the hydroxypropyl methyl celluloses E5, accordingly, the problem that metal ions react with an existing active ingredient is fundamentally solved, and long-term storage and storage are facilitated.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a pharmaceutical preparation for external use, in particular to an adapalene gel and a preparation method thereof. Background technique [0002] Adapalene (Adapalene, CD271) is a new naphthoic acid derivative, which belongs to the i-th generation of retinoic acid drugs. Compared with retinoic acid, its basic molecular structure has been widely modified. The external preparation is 0.1% adapalene gel, which has good anti-inflammation and improves the differentiation ability of epidermal keratinocytes (keratinocytes). It has been clinically shown to have a good curative effect on acne, and is especially suitable for the treatment of mild and moderate acne , has better tolerance and lower side effects than other tretinoin. [0003] A large number of experimental studies have shown that adapalene is very easy to react with metal ions and degrade. How...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/192A61K47/38A61K47/34A61P17/10A61K47/26
Inventor 王福东殷雨林邓建华
Owner 江苏小林制药有限公司
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