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Sensitive fluorescent lighting probe method for determining CMC (critical micelle concentration) of surfactant

A critical micelle concentration and surfactant technology, applied in luminescent materials, chemical instruments and methods, chemiluminescence/bioluminescence, etc., can solve problems affecting micelle formation, failing to find type II probes, reducing TPE sensitivity, etc. , to achieve the effects of eliminating errors, high sensitivity, and simplifying operation steps

Active Publication Date: 2013-11-27
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the TPE disclosed in this document must be used at a very low concentration (0.5 μM), otherwise it will affect the formation of micelles, which reduces the sensitivity of TPE to determine CMC
[0005] So far, no compound has been found as an ideal type II probe

Method used

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  • Sensitive fluorescent lighting probe method for determining CMC (critical micelle concentration) of surfactant
  • Sensitive fluorescent lighting probe method for determining CMC (critical micelle concentration) of surfactant
  • Sensitive fluorescent lighting probe method for determining CMC (critical micelle concentration) of surfactant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] S1. Dimthyl 1,2,3,6-tetrahydro-1,2,3 -triphenylpyrimidine-4,5-dicarboxylate, compound 1) was prepared as a stock solution at a concentration of 1 mM in ethanol.

[0058]

[0059] Compound 1

[0060] S2. In a 100mL volumetric flask, add 288 mg sodium dodecyl sulfate (SDS), add double distilled water until the sample is dissolved, then add 0.6 mL of the stock solution prepared by S1., and then use double distilled water to determine In the constant solution, the concentration of SDS is 10 mM, and the concentration of compound 1 is 6 μM in the constant solution.

[0061]S3. Prepare the non-fluorochrome solution prepared in S2. to prepare SDS sample solutions with different concentrations for the determination of fluorescence and SDS critical micelle concentration (CMC). Specific steps are as follows:

[0062] At 25°C, according to Table 1, take different volumes of the fixed solution prepared in step S2. into eleven 10 mL volumetric flasks, add double distilled water...

Embodiment 2

[0069] S1. Dimethyl 1,3-bis(4-bromophenyl)-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate (dimethyl 1,3-bis(4 -bromophenyl)-1,2,3,6-tetrahydro-2-phenylpyrimidine-4,5-dicarboxylate, compound 2) was prepared as a stock solution with a concentration of 1 mM in ethanol.

[0070]

[0071] Compound 2

[0072] S2. In a 100mL volumetric flask, add 576 mg sodium dodecyl sulfate (SDS), add double distilled water until the sample is dissolved, then add 1.2 mL of the stock solution prepared by S1., and then use double distilled water to determine In order to obtain a non-fluorescence fixed solution, the concentration of SDS in the fixed solution is 20 mM, and the concentration of compound 2 is 12 μM.

[0073] S3. Prepare the non-fluorochrome solution prepared in S2. to prepare SDS sample solutions with different concentrations for the determination of fluorescence and SDS critical micelle concentration (CMC). Specific steps are as follows:

[0074] At 27°C, according to Table 2, tak...

Embodiment 3

[0080] S1. Dimethyl 1,2,3,6-tetrahydro-2 -phenyl-1,3-dip-tolylpyrimidine-4,5-dicarboxylate, compound 3) was prepared as a stock solution with a concentration of 1 mM in THF.

[0081]

[0082] Compound 3

[0083] S2. In a 100mL volumetric flask, add 72.8 mg cetyl trimethyl ammonium bromide (CTAB), add double distilled water until the sample is dissolved, then add 1 mL of the stock solution prepared by S1., then Double-distilled water was used for constant volume, so that a non-fluorescent constant solution was obtained. In the constant solution, the concentration of CTAB was 2 mM, and the concentration of compound 3 was 10 μM.

[0084] S3. Use the non-fluorescent solution prepared in S2. to prepare different concentrations of CTAB sample solutions for the determination of fluorescence and CTAB critical micelle concentration (CMC). Specific steps are as follows:

[0085] According to Table 3, take different volumes of the fixed solution prepared according to step S2. into ...

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Abstract

The invention discloses a method for determining the CMC (critical micelle concentration) of surfactant. The new method for determining the CMC of surfactant is designed by using an aggregation-induced emission organic substance having a structure shown in Formula (I) as a fluorescent probe according to the characteristics of the organic substance. The method is to determine the CMC through the highest fluorescence intensity mutation point of the probe, while the CMC fluorescent determination method reported by others is to determine the CMC through the lowest fluorescence intensity mutation point of the probe. Therefore, the CMC fluorescent determination method disclosed by the invention has higher sensitivity in comparison with the reported CMC fluorescent determination method. According to the CMC fluorescent determination method disclosed by the invention, when surfactant detection solutions of different concentrations are prepared, the concentration of the fluorescent probe does not need to be maintained at the same level, thus greatly simplifying the operation steps and eliminating the error caused by measuring the fluorescent probe repeatedly. The Formula (I) is shown in the specification.

Description

technical field [0001] The invention relates to the technical field of surfactant analysis, in particular to a method for measuring the critical micelle concentration of surfactants. Background technique [0002] Surfactants have various properties, such as wetting, emulsifying, foaming, dissolving, dispersing, washing, corrosion resistance, antistatic, etc., and are widely used in various fields, such as medicinal chemistry, synthetic chemistry, materials science, biology wait. At a certain concentration, that is, the critical micelle concentration (CMC) concentration, surfactants begin to form thermodynamically stable micelles, and at the same time, various properties change significantly. Therefore, the determination of CMC is of great significance in practical applications, and it is a hot spot in the research of physical chemistry and analytical chemistry. The currently developed CMC determination method is to determine the CMC value by utilizing the sudden change in ...

Claims

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Application Information

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IPC IPC(8): G01N21/76C09K11/06
Inventor 朱秋华刘叔文
Owner SOUTHERN MEDICAL UNIVERSITY
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