Fluorescence molecular tomography reconstruction method based on alternative iterative operation

Abstract

The invention discloses a fluorescence molecular tomography reconstruction algorithm based on an alternative iterative operation, which is characterized in that a weighted algebraic reconstruction technique and a steepest descent method are used alternately for solving. The fluorescence molecular tomography reconstruction algorithm comprises the following steps that (1), measurement data is acquired; (2), a linear relationship between the measurement data and target distribution is established; (3), a 2 norm minimization problem with a constraint condition is constructed; and (4), the weighted algebraic reconstruction technique and the steepest descent method are used alternately for solving the minimization problem, and a target distribution diagram is obtained. According to the fluorescence molecular tomography reconstruction algorithm, based on a light transmission theory and a finite element method, prior information such as an optical characteristic parameter and an anatomical structure is used, multipoint excitation and multipoint measurement are adopted, and the measurement data is obtained as far as possible, so that the pathosis of the problem is reduced; the weighted algebraic reconstruction technique and the steepest descent method are used alternately for solving the problem, so that a reconstruction result of fluorescence molecular tomography is improved effectively; and the fluorescence molecular tomography reconstruction algorithm has an important application value in the fields of molecular imaging, reconstruction algorithms and the like.

Description

technical field [0001] The invention belongs to the field of molecular imaging, and further relates to a fluorescence molecular tomography reconstruction algorithm based on alternate iterative operations, which can be used for inverse reconstruction of in vivo fluorescence molecular tomography. Background technique [0002] Fluorescence molecular tomography (hereinafter referred to as FMT) is a new optical molecular imaging technology that has emerged in recent years. It uses certain molecules (generally mainly polycyclic aromatic hydrocarbons or heterocyclic compounds, etc.) Needles, fluorescent dyes, etc. mark reconstruction targets. Under the irradiation of an external excitation light source, the molecules will absorb the external excitation light, and then emit photons, and the intensity of the generated light is proportional to the number of marked targets. Outside the reconstruction target area, the photons transmitted out of the reconstruction target area can be dire...

AI Technical Summary

Problems solved by technology

At the same time, the signal detected by the optical detection instrument at the boundary of the reconstruction target area is the value of the boundary point, the number is limited, and the number of points inside the solution area is very large

Solving a large number of unknowns from a small amount of measurement data is an ill-posed problem with serious ill-conditioning, and its solution is not unique and is easily affected by measurement errors and noise

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