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Andrographolide suspension and preparation method and medical application thereof

A technology of andrographolide and suspension, which is applied in the fields of pharmaceutical formulations, antipyretics, anti-inflammatory agents, etc., and can solve the problems of reducing the number of medications, large drug loading, and few excipients

Inactive Publication Date: 2013-10-30
CHANGZHOU TARGET MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Suspension solves the problem of administration of insoluble drugs, uses less excipients, has a large drug loading capacity, and can significantly improve bioavailability and reduce the number of medications

Method used

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  • Andrographolide suspension and preparation method and medical application thereof
  • Andrographolide suspension and preparation method and medical application thereof
  • Andrographolide suspension and preparation method and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Mortar grinding preparation, configure according to the prescription in Table 1, weigh the prescription amount of andrographolide, put it in the mortar, follow the order of the components in the prescription, add the auxiliary materials in the table in turn, grind each for 5 minutes, and finally add Distilled water, made 10ml altogether, grind together 10min, obtain each prescription amount andrographolide suspension.

[0032] Table 1 andrographolide suspension prescription

[0033]

[0034]

[0035]

[0036]

[0037] Explanation: ——means no addition.

Embodiment 2-4

[0038] Embodiment 2-4: preparation by wet grinding

Embodiment 2

[0039] Embodiment 2: take andrographolide 10g, add distilled water 100ml, put in the wet grinder (Mini-Easy nano grinding equipment), add Tween 80 0.3g, glycerin 0.5g, sodium carboxymethylcellulose solution 0.5g, Grinding for 1 hour in circulation to obtain a suspension of andrographolide.

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Abstract

The invention discloses an andrographolide suspension capable of obviously improving oral bioavailability and realizing slow release by intramuscular injection or hypodermic injection, a method for preparing the suspension and a medical application of the suspension. The preparation consists of a general suspension and a dry suspension and can be taken orally or subjected to hypodermic injection or intramuscular injection. The method is characterized in that the raw materials are processed to obtain micron-sized or nanometer-sized particles, a certain amount of auxiliary materials are added, thus the bioavailability is improved and the stability of the preparation is ensured. The whole preparation process is simple and controllable, and the industrial production can be realized. Compared with a preparation prepared from common raw materials, the preparation prepared by the preparation method, disclosed by the invention, has the advantages that the bioavailability can be obviously improved by taking orally; and the low release effect can be realized after intramuscular injection or hypodermic injection.

Description

technical field [0001] The invention relates to preparations of insoluble natural products, in particular to andrographolide suspensions, preparation methods and medical applications thereof. Background technique [0002] Andrographolide is a diterpene lactone compound extracted from the whole grass or leaves of Andrographis Paniculata (Burm.f) Ness, a plant of the family Acanthaceae. Its structural formula is as follows: [0003] [0004] Andrographolide is the main active ingredient of the natural plant Andrographis paniculata. It has the effects of dispelling heat and detoxification, reducing inflammation and relieving pain, and has special effects on bacterial and viral upper respiratory tract infections and dysentery. It is known as a natural antibiotic drug. This product is a diterpene lactone compound, which is insoluble in water and can only be administered orally. However, common preparations such as andrographolide tablets and capsules currently used in clinics...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K9/19A61K31/365A61P29/00A61P31/04A61P31/12A61P35/00
Inventor 刘珂许卉邹晓丽郎跃武
Owner CHANGZHOU TARGET MEDICINE TECH CO LTD
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