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A kind of hemostatic starch and preparation method thereof

A technology of starch and modified starch, which is applied in medical science, bandages, absorbent pads, etc., can solve the problems of low water absorption and unstable preparation of modified starch, and achieve the effects of improving water absorption performance, stable preparation, and convenient preparation

Active Publication Date: 2016-11-30
江苏德威兰医疗器械股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] An object of the present invention is to provide a new hemostatic starch, which has good water absorption, safety, and stable performance, and overcomes the shortcomings of low water absorption and unstable preparations of modified starch in the prior art.

Method used

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  • A kind of hemostatic starch and preparation method thereof
  • A kind of hemostatic starch and preparation method thereof
  • A kind of hemostatic starch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Screening test of preferred substance dosage and step parameters of hemostatic starch of the present invention

[0048] The selection and consumption of each substance in the reaction are shown in the table below

[0049] Table 1.

[0050]

[0051]

[0052]

[0053]

[0054]

[0055]

[0056]

[0057]

[0058]

[0059] Combinations of the above 1-45 reactants were used to prepare hemostatic starch 1-45 according to the following method:

[0060] Method 1: Put sodium hydroxide, modified starch and alcohol into the reactor, mix and stir to dissolve completely;

[0061] Add cross-linking agent to the reactor, react for 50min;

[0062]Introduce nitrogen gas into the reactor for 5 minutes, then add etherifying agent for reaction, and infuse nitrogen gas for 5 minutes again, seal the reactor, heat the water area to 40°C, and stir for 2 hours;

[0063] Neutralize the above reactant to pH6.5 with dilute acid;

[0064] Suction filtration,...

Embodiment 2

[0071] Embodiment 2 control group experimental design

[0072] According to the methods of Examples 1, 3, 4, and 5 of patent cn200710199682.3, hemostatic starches A, C, D, and E were respectively prepared as the control group. The specific steps are as follows:

[0073] Put 2g of pregelatinized hydroxypropyl distarch phosphate 51# into 30ml of water, stir continuously to make the starch granules fully swell and disperse in water to form a uniform suspension, then filter with suction, wash with alcohol, and dry to obtain hemostatic starch a.

[0074] Put 2g of carboxymethyl starch 66# into 30ml of water, stir constantly to make the starch granules fully swell and disperse in water to form a uniform suspension, then pour it into a container, then suction filter, wash with alcohol, and dry to obtain hemostatic starch c.

[0075] 3g cross-linked carboxymethyl starch 66# + As for 30ml of water, stir constantly to make the starch granules fully swell and disperse in water to form...

Embodiment 3

[0077] The detection of the water absorption rate and water absorption rate of embodiment 3 hemostatic starch

[0078] The water absorption rate of starch is determined by centrifugation, that is, about 0.025g of starch is placed in 2ml of water, equilibrated for 10min, then placed in a centrifuge, centrifuged at 500rpm for 10 minutes, taken out, and weighed to calculate the amount of residual liquid. Each sample is tested for 6 Times to average.

[0079] The water absorption rate of starch was observed by the OCA40Micro video contact angle measuring instrument from Dataphysics, Germany.

[0080] Experimental results: The water absorption ratio and water absorption rate of the 90 kinds of hemostatic starches obtained by the method of Example 1 and the hemostatic starches A, C, D, and E obtained by the control group of Example 2 are shown in the following table:

[0081] Table 2

[0082]

[0083]

[0084]

[0085]

[0086] Analysis of results:

[0087] The follow...

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Abstract

The invention belongs to the field of hemostatic starch, and relates to a hemostatic starch and an application thereof. In order to solve the problem of poor water absorption of hemostatic starch in the prior art, the technical solution of the present invention is to mix various modified starches in the prior art with sodium hydroxide, modified starch and alcohol, and through steps such as crosslinking and etherification to finally Preparation of highly water-absorbing hemostatic starch. The hemostatic starch has excellent water absorption effect, is safe and stable, and is a biocompatible hemostatic starch that can be directly used on bloody wounds.

Description

technical field [0001] The invention relates to a hemostatic starch and a preparation method thereof, in particular to a biocompatible hemostatic starch which can be directly used on bloody wounds and a preparation method thereof. Background technique [0002] Bleeding is the most likely phenomenon in accidents and medical treatment. A large amount of bleeding will endanger human life. Therefore, it is necessary to stop bleeding in time for bleeding wounds. [0003] With the development of medicine, there are many kinds of hemostatic materials. In terms of biocompatibility, commonly used biocompatible hemostatic materials include: absorbable gelatin starch, collagen starch and other gelatin hemostatic materials; oxidized cellulose, oxidized regeneration Cellulose hemostatic materials; chitosan / chitin, starch polysaccharides and other natural biopolysaccharide hemostatic materials, etc. [0004] The content of the present invention relates to the hemostatic material of starc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B31/16C08B31/00C08B31/12A61L15/28A61L31/04
Inventor 刘泊志
Owner 江苏德威兰医疗器械股份有限公司
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