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Needle assemblies, injection devices

A technology of injection device and components, which is applied in the direction of needles and instruments introduced into the body, can solve the problems of animal blood circulation obstruction, animal death, etc., and achieve the effects of reducing the possibility of bile leakage, reducing mortality, and increasing transfection efficiency

Active Publication Date: 2015-09-02
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, large-volume high-pressure injections can easily block the blood circulation of animals and directly lead to animal death.

Method used

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  • Needle assemblies, injection devices

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Such as figure 1 As shown, the needle assembly of the present application, an embodiment thereof, includes a hose 11, a first needle barrel 12, an injection sleeve 13 and a connecting piece 14, the connecting piece 14 is connected with the syringe, and the first needle barrel 12 is made of metal The injection sleeve 13 is a soft rubber tube, the injection sleeve 13 includes a second needle barrel and a second needle point, the hose 11 connects the first needle barrel 12 and the connecting piece 14, and the second needle barrel is sleeved on the first needle barrel 12 superior. The length of the injection cannula 13 is 4-6 mm, and the length of the second needle tip is 2-3 mm.

[0025] In one embodiment, the injection cannula 13 is made of polyethylene, and the first needle barrel 12 is made of stainless steel.

[0026] In one embodiment, the outer diameter of the injection sleeve 13 is less than or equal to 1 mm, and the inner diameter of the injection sleeve 13 is gr...

Embodiment 2

[0029] Such as figure 1 As shown, the injection device of the present application, an embodiment thereof, includes a syringe (not shown), a hose 11, a first needle barrel 12, an injection sleeve 13 and a connecting piece 14, and the connecting piece 14 is connected with the syringe. A needle barrel 12 is made of metal, and the injection sleeve 13 is a soft rubber tube. The injection sleeve 13 includes a second needle barrel and a second needle point. The flexible pipe 11 connects the first needle barrel 12 and the connector 14, and the second needle barrel cover Set on the first needle stem 12. The length of the injection cannula 13 is 4-6 mm, and the length of the second needle tip is 2-3 mm.

[0030] In one embodiment, the injection cannula 13 is made of polyethylene, and the first needle barrel 12 is made of stainless steel.

[0031] In one embodiment, the outer diameter of the injection sleeve 13 is less than or equal to 1 mm. The inner diameter of the injection sleeve ...

Embodiment approach

[0035] The establishment method of the mouse model of the present application, one embodiment thereof, comprises the following steps:

[0036] Step 202: Take BALB / c mice for experiment, 6-8 weeks old;

[0037] Step 204: Use the injection device of the present application to perform retrograde bile duct injection.

[0038] The mouse model establishment method of the present application is based on the mouse liver-targeted gene transfer technology, and the vector and DNA are retrogradely injected into the mouse gallbladder, and the vector and DNA can be changed into commonly used clinical chemotherapy drugs or other therapeutic drugs.

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Abstract

The invention discloses a syringe needle assembly and an injection device. The syringe needle assembly comprises a hose, a first needle stem, an injection casing and a connecting piece connected with a syringe, wherein the first needle stem is made of metal; the injection casing is a flexible rubber hose and comprises a second needle stem and a second needlepoint; the first needle stem is connected with the connecting piece by the hose; and the second needle stem is sleeved on the first needle stem. The invention also discloses an establishment method of a mouse model. According to the syringe needle assembly, since the first needle stem is made of metal, the injection casing comprises the second needle stem and the second needlepoint, the second needle stem is sleeved on the first needle stem, and the injection casing is the flexible rubber hose, so that the injection casing can be conveniently held by fingers to be pierced into the gallbladder, the possibility of bile leakage caused by piercing of the gallbladder in a piercing process of the second needlepoint is reduced, genes are reversely injected into the liver through the mouse gallbladder to achieve effective gene delivery of target organs and increase the transfection efficiency of the genes, and meanwhile, the death rate of a laboratory mouse is also reduced.

Description

technical field [0001] The present application relates to a needle assembly, an injection device and a method for establishing a mouse model. Background technique [0002] The liver is the largest metabolic-based solid organ in the human body. Its unique morphological structure and chemical composition characteristics endow the liver with complex and diverse biochemical functions. The liver is supplied with blood by the hepatic artery and the portal vein, so that the liver cells can obtain sufficient oxygen and nutrients; there are also dual output channels of the hepatic vein and the biliary system in the liver, which can export its metabolites or other tissue utilization; the liver is rich in hepatic Sinusoids provide a powerful place for material exchange between liver cells and blood; the liver also contains rich enzyme systems, enabling liver cells to have special metabolic functions in addition to normal metabolic functions, such as synthesizing coagulation factors, ur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M5/32
Inventor 高琳邱本胜王志勇谢丽斯陈志英何成宜南翔
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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