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Anti-adhesion liquor for wound washing and surgery and preparation method and application of anti-adhesion liquor

A surgical operation and anti-adhesion technology, which is applied in surgical drugs, surgery, extracellular fluid diseases, etc., can solve the problems of inhibiting the normal growth of tissue cells, adverse reactions, and strong acidity of degradation products, so as to achieve good flushing effect and improve surgical procedures. Environment, flushing effect is obvious effect

Active Publication Date: 2013-08-28
ARNOKANG NINGXIA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The third-generation materials are currently widely used clinically, but these products more or less have some shortcomings that are difficult to control in terms of purity and degradation rate, and some products have high osmotic pressure and cause adverse reactions
However, it has poor adhesion, is not easy to fix, and is difficult to control its degradation rate. It often loses its effect due to too fast degradation, and the degradation products cause local strong acidity, which inhibits the normal growth of tissue cells.
Chitosan anti-adhesion products, such as chitosan anti-adhesion film and chitosan anti-adhesion liquid, are deacetylated dextran extracted from shrimp shells or crab shells, which have certain anti-adhesion effects. However, its molecular weight is difficult to control in equal amounts, and it is difficult to completely remove the specific protein during extraction, which leads to high risks in use and prone to allergies

Method used

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  • Anti-adhesion liquor for wound washing and surgery and preparation method and application of anti-adhesion liquor
  • Anti-adhesion liquor for wound washing and surgery and preparation method and application of anti-adhesion liquor
  • Anti-adhesion liquor for wound washing and surgery and preparation method and application of anti-adhesion liquor

Examples

Experimental program
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Effect test

example 1

[0112] Recipe (weight)

[0113] Preparation of surgical anti-adhesion fluid:

[0114]

[0115] 1. Weigh 3Kg of sodium carboxymethylcellulose that meets the standard, and slowly add it to the equipment (A) filled with 100L of water for injection. Stir to dissolve. After dissolving into a transparent glue, add 5moL / L NaOH prepared in advance to adjust the pH value to 9-10, stir and mix well and let it stand for 3-4 hours; take 1moL / L HCL to adjust the pH value to 5-7. Use a filter membrane to filter into a device with a capacity of about 400L (B).

[0116] 2. Dissolve the required amount of sodium chloride, fucoidan oligosaccharide, polyethylene glycol, and hydroxyethyl starch in a small amount of water for injection, and add 0.5% by volume of the injection with activated carbon to dissolve and circulate for 30 minutes. Filter through a 0.45 filter into B equipment.

[0117] 3. Add water for injection to equipment B to make the capacity reach 300L, stir to mix the glue, m...

example 2

[0142] Recipe (weight)

[0143]

[0144] 1. Weigh 1Kg of sodium carboxymethylcellulose that meets the standard, and slowly add it to the equipment (A) filled with 100L of water for injection. Stir to dissolve. After it dissolves into a transparent glue, add 5moL / L NaOH prepared in advance to adjust the pH value to 9-10, stir and mix well and let it stand for 3-4 hours; take 1moL / L HCL to adjust the pH value to 5-7. Use a 500nm filter membrane to filter into a device with a capacity of about 400L (B).

[0145] 2. Dissolve the required amount of fucoidan oligosaccharides, sodium chloride, polyethylene glycol, in a small amount of water for injection, add 0.5% injection by volume and dissolve it with activated carbon for 30 minutes. Filter through a 0.45 filter into a device filled with carboxymethylcellulose.

[0146] 3. Add water for injection to equipment B to make the capacity reach 300L, stir to mix the glue, measure the osmotic pressure and adjust it to the acceptable...

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PUM

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Abstract

The invention relates to anti-adhesion liquor for wound washing and surgery and a preparation method and application of the anti-adhesion liquor. The anti-adhesion liquor comprises the following components in percentage by weight: 0.1%-5% of sodium carboxymethylcellulose, 0.1%-10% of brown seaweed oligosaccharide, 0.1%-5% of hydroxyethyl starch, 0.1%-5% of polyethylene glycol, 0.1%-0.9% of sodium chloride, and the balance of water for injection. The preparation method is characterized in that the sodium carboxymethylcellulose, the hydroxyethyl starch, the brown seaweed oligosaccharide, the polyethylene glycol, the sodium chloride and the water for injection are mixed through stirring or crosslinking so as to prepare membranoid substance or liquid. The anti-adhesion liquor has the multiple functions of stopping bleeding, resisting bacterium, resisting adhesion, and promoting healing.

Description

technical field [0001] The invention relates to an auxiliary article for surgical operations in the medical field, an anti-adhesion liquid for wound washing and surgical operations, a preparation method and application thereof. Background technique [0002] In surgery, adhesions are abnormal structures in which fibrous bands of connective tissue join together with adjacent tissues or organs. Adhesions can range in size from a thin film to a dense vascular scar. Adhesion formation is universal, and it is reported that 50%-100% of abdominal and pelvic surgeries can lead to different degrees of adhesions. Clinically serious complications caused by adhesions include intestinal obstruction, infertility, and chronic pelvic pain. It increases the difficulty of reoperation and the potential for further complications. The purpose of preventing adhesions is to eliminate or reduce the incidence and severity of adhesions on the premise of ensuring normal wound healing and avoiding inf...

Claims

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Application Information

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IPC IPC(8): A61K31/765A61K31/715A61L31/04A61L31/14A61L15/42A61P41/00A61P31/04A61P7/04A61P17/02A61K31/717A61K31/718
Inventor 张岩
Owner ARNOKANG NINGXIA BIOTECH
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