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Application of SIRT1 (silent information regulator 1) in preparation of medicines for treating severe burns or wounds

A 1.SIRT1, severe burn technology, applied in the direction of gene therapy, drug combination, pharmaceutical formulation, etc., can solve the problems that have not been seen, and achieve the effect of improving living conditions, clear structure, and single drug structure

Inactive Publication Date: 2013-08-14
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there are no relevant reports or written records on the research and application of SIRT1 and SIRT1 agonists in the treatment of severe burns (wounds)

Method used

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  • Application of SIRT1 (silent information regulator 1) in preparation of medicines for treating severe burns or wounds
  • Application of SIRT1 (silent information regulator 1) in preparation of medicines for treating severe burns or wounds
  • Application of SIRT1 (silent information regulator 1) in preparation of medicines for treating severe burns or wounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0032] Experimental Materials:

[0033] SIRT1 activator: The SIRT1 agonist used in this experiment is resveratrol, which can be purchased directly from the market. Resveratrol in this experiment was purchased from Sigma alone.

[0034] The experimental animal SD rats used in the experiment were purchased from the Experimental Animal Center of Fourth Military Medical University, and were kept in the second-level animal room, free to drink water and eat, and kept in an alternate feeding environment of 12 hours day and 12 hours night.

[0035] Establishment of severe burn (trauma) injury model

[0036] The severe burn model used in this experiment is: more than 30% TBSAⅢ°rat burn model.

[0037] Production process: Adult SD rats, half male and half female, weighing (200-230) g, were anesthetized with isoflurane inhalation 24 hours before scalding, and 10% sodium sulfide was depilated on the back and side abdomen to form 30%-40% of the scalded area. Before scalding, the patient...

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PUM

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Abstract

The invention discloses an application of an SIRT1 (silent information regulator 1), and in particular an application of an SIRT1 in preparation of medicines for treating severe burns or wounds. The SIRT1 can be used for reducing the mortality of severely burned rats, obviously improving the survival conditions of the early severely burned rats as well as reducing the apoptosis of tissue cells of multiple organs (heart, lungs, kidneys and the like), plays an important role in treating severe burns or wounds, and has wide application prospects.

Description

technical field [0001] The invention relates to a new application of SIRT1, in particular to an application of SIRT1 in the preparation of medicines for treating severe burns or trauma. Background technique [0002] Burns are traumas that coexist with humans. Severe burns generally refer to large-area burns or deep burns. In my country, burns with an area of ​​more than 30% and third-degree areas of more than 10% are classified as severe burns. This type of burn is complicated and affects all systems of the body. , a variety of life-threatening complications can occur. With the rapid development of modern human civilization, the factors causing burn (trauma) injuries have become more and more complex. The use of various high-performance fuels in modern industry, modern wars and terrorist activities have caused severe burn (trauma) injuries The rate has increased even more. Therefore, the study of severe burn (trauma) injury under the new situation is still the focus and dif...

Claims

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Application Information

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IPC IPC(8): A61K38/50A61K45/00A61K48/00A61K31/05A61P17/02
Inventor 白晓智胡大海汤朝武石继红朱雄翔韩军涛董茂龙
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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