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Dynamic bidirectional-stretch in-situ online-observation cell biomechanics loading device

A biaxial stretching and biomechanical technology, applied in biochemical cleaning devices, enzymology/microbiology devices, biochemical equipment and methods, etc., can solve the problem of inability to realize online observation of dynamic loading of adherent cells.

Active Publication Date: 2013-07-03
INST OF MECHANICS - CHINESE ACAD OF SCI
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  • Abstract
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Problems solved by technology

[0003] With the in-depth study of mechanical stress regulating cell biological functions, a variety of devices for stretching and loading cells in vitro have been developed, mainly including vacuum (negative pressure) loading devices, liquid (positive pressure) pressurizing devices, dual Four-point bending beam loading device, two-way strain loading device, etc., but all cannot achieve the purpose of online observation of dynamic loading of adherent cells

Method used

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  • Dynamic bidirectional-stretch in-situ online-observation cell biomechanics loading device

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Embodiment Construction

[0015] Such as figure 1 As shown, the present invention includes: a base film 2 , a fixing clip 3 , a displacement support arm 4 and a driving part 7 . Adherent cells grown on basement membrane 2 for observation. There are two fixing clips 3, which respectively clamp the two sides of the basement membrane 2. There are also two displacement support arms 4, which are arranged corresponding to the fixing clips 3, and are used to respectively support the fixing clips 3, and the fixing clips 3 are movably arranged on the guide rail 6. The driving part 7 is used to drive the displacement support arm 4 to move symmetrically and oppositely on the guide rail 6, so as to bidirectionally stretch the base film 2 .

[0016] Such as figure 1 As shown, in the embodiment of the present invention, the drive portion 7 includes: a drive motor 71, a varicose arm 75, a deflection wheel chute 73, a deflection wheel 74 and a motor bracket 72; the drive motor 71 is arranged on the motor bracket 3,...

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Abstract

The invention discloses a dynamic bidirectional-stretch in-situ online-observation cell biomechanics loading device. The loading device comprises a base film for the growth of an adherent cell used for being observed; two fixing clips for clamping the two sides of the base film respectively, two displacement support arms for supporting the fixing clips respectively, and a driving part, wherein the fixing clips are movably arranged on a rail, and the driving part is used for driving the displacement support arms to perform symmetrical opposite-direction displacement on the rail so as to conduct bidirectional-stretch on the base film. According to the invention, by conducting the stretch with a certain frequency and a certain range on the cell growing on the biocompatible film, morphologic change, cytoskeleton reorganization, signal transduction and other responses of the cell in different action times can be observed.

Description

technical field [0001] The present invention relates to a cell device for biomechanical, mechano-biological coupling, and biomedical research. Background technique [0002] The revelation of the stress-growth relationship is a major discovery in biomechanics, and cells are the basic unit of life. The tensile force is the main factor that determines the shape and function of cells. Therefore, the development of experimental devices that apply tensile strain to cultured cells in vitro has become a key issue in solving the coupling of mechanics and biology. [0003] With the in-depth study of mechanical stress regulating cell biological functions, a variety of devices for stretching and loading cells in vitro have been developed, mainly including vacuum (negative pressure) loading devices, liquid (positive pressure) pressurizing devices, dual Axial equi-strain loading devices, four-point bending beam loading devices, two-way strain loading devices, etc., but none of them can a...

Claims

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Application Information

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IPC IPC(8): C12M1/00
Inventor 龙勉高宇欣吕东媛章燕
Owner INST OF MECHANICS - CHINESE ACAD OF SCI
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