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Research for influence on endocytosis of cell transferrins of UNC-51 kinase

A technology of UNC-51 and transferrin, applied in the field of biochemistry, can solve the problem that the molecular and cellular mechanism of transferrin is not very clear.

Inactive Publication Date: 2013-06-19
彩虹天健康科技研究(北京)有限责任公司
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Problems solved by technology

Although endocytosis is related to the cytoskeleton, the molecular and cellular mechanisms of transferrin endocytosis are not well understood

Method used

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  • Research for influence on endocytosis of cell transferrins of UNC-51 kinase
  • Research for influence on endocytosis of cell transferrins of UNC-51 kinase

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Embodiment Construction

[0010] 【1】Observation by laser scanning fluorescence confocal microscope

[0011] DAPI was used for nuclear staining, and TexasRed and FITC were used for staining of UNC-51 and tubulin, respectively. A ZeissLSM510 confocal microscope was used for cell observation and recording.

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Abstract

The invention discloses research for the influence on the endocytosis of cell transferrins of UNC-51 kinase, wherein maintenance for the stable level of iron elements in cells and body is necessary to the health of life; cell absorption and iron transport are mainly performed via the endocytosis of cell transferrins; the molecular mechanism and the cell mechanism of the endocytosis of cell transferrins are not clear yet; and interpretation for the molecular mechanism and the cell mechanism of the endocytosis of cell transferrins has important significance for prevention and treatment for neurological diseases. The research shows that the COS-7 cells for over-expressing Myc-tagged UNC-51 kinase inhibit the endocytosis of cell transferrins due to that the over-expressed UNC-51 kinase in the COS-7 cells have the function of promoting the dynamic changes of cytoskeletons, thus blocking the recirculation of the complex particles of transferrins, and achieving the effect of preventing the endocytosis of cell transferrins. The research shows the first mode of participating in the endocytosis of cell transferrins of UNC-51 kinase.

Description

Technical field: [0001] The invention belongs to the fields of biochemistry, cell biology, neuroscience and the like, and proposes a new mechanism for affecting the endocytosis of cell transferrin. Background technique: [0002] Iron (Fe) is necessary for the structure and function of cells and life, and maintaining a stable level of iron in the body is also necessary for life and health. Cellular uptake and transport of iron is mainly carried out through the endocytosis of transferrin (transferrin). Although endocytosis is related to the cytoskeleton, the molecular and cellular mechanisms of transferrin endocytosis are not well understood. UNC-51 kinase directly affects cytoskeleton dynamics, leading us to think that UNC-51 kinase may also affect endocytosis of intracellular transferrin. This study demonstrates for the first time that UNC-51 kinase specifically affects the endocytosis of intracellular transferrin. Invention content: [0003] The present invention aims ...

Claims

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Application Information

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IPC IPC(8): C12Q1/48C12Q1/02
Inventor 田怀泽李素云田华希
Owner 彩虹天健康科技研究(北京)有限责任公司
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